Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,661 questions · 2,751 findings · 453 reviews

No studies found 593 · 21.6%GRADE not reported 277 · 10.1%Very low 538 · 19.6%Low 712 · 25.9%Moderate 516 · 18.8%High 115 · 4.2%

Primary‐level worker‐led collaborative care vs usual care

Service utilisation ‐ referral to mental health team ‐ long term (7 to 12 months post intervention)Â · adults with common mental disorders

Primary‐level worker‐led collaborative care may leads to lower service utilisation ‐ referral to mental health team ‐ long term (7… compared with usual care (low certainty).

1 finding from 1 review

Intervention not reported

Long‐term neurological sequelae other than hearing loss defined as sequelae present between 6 weeks after hospital discharge and the last time point reported in the study · children with acute bacterial meningitis

The intervention may leads to higher long‐term neurological sequelae other than hearing loss defined as… (low certainty).

1 finding from 1 review

Anti‐IL‐4Rα mAb (dupilumab) vs placebo (on top of topical steroids)

Adverse events ‐ nasopharyngitis, including sore throat · patients with severe chronic rhinosinusitis with nasal polyps

Anti‐IL‐4Rα mAb (dupilumab) showed no clear difference in adverse events ‐ nasopharyngitis, including sore throat (longest… compared with placebo (on top of topical steroids) (low certainty).

1 finding from 1 review

Lamotrigine vs lithium

Withdrawal from treatment due to any reason, 6‐12 months after intervention initiation (long term) · bipolar disorder

Lamotrigine showed no clear difference in withdrawal from treatment due to any reason, 6‐12 months after… compared with lithium (moderate certainty).

1 finding from 1 review

Lamotrigine vs lithium

Any reported adverse effects 6‐12 months after initiating the intervention (long term) · bipolar disorder

Lamotrigine probably leads to lower any reported adverse effects 6‐12 months after initiating the… compared with lithium (moderate certainty).

1 finding from 1 review

Lamotrigine vs placebo

Withdrawal from treatment due to any reason, 6‐12 months after intervention initiation (long term) · bipolar disorder

Lamotrigine probably leads to lower withdrawal from treatment due to any reason, 6‐12 months after… compared with placebo (moderate certainty).

1 finding from 1 review

Lamotrigine vs placebo

Any reported adverse effects 6‐12 months after initiating the intervention (long term) · bipolar disorder

Lamotrigine showed no clear difference in any reported adverse effects 6‐12 months after initiating the… compared with placebo (moderate certainty).

1 finding from 1 review

Hydroxychloroquine (HCQ) vs placebo or usual care

Participants with prolongation of QT‐interval on ECG · adults with mild to severe COVID‐19

It is very uncertain whether hydroxychloroquine (HCQ) changes participants with prolongation of QT‐interval on ECG compared with standard care or placebo (very low certainty).

1 finding from 1 review