Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,733 questions · 1,794 findings · 326 reviews · Headline outcomes only

No studies found 243 · 13.5%GRADE not reported 96 · 5.4%Very low 597 · 33.3%Low 506 · 28.2%Moderate 303 · 16.9%High 49 · 2.7%

Psychological interventions (including health education) vs usual care

Proportion of participants returning to work in the short term (up to 6 months) · patients with coronary heart disease

It is very uncertain whether psychological interventions (including health education) changes proportion of participants returning to work in the short term (up… compared with usual care (very low certainty).

1 finding from 1 review

Combined interventions vs usual care

Proportion of participants returning to work in the short term (up to 6 months) · patients with coronary heart disease

Combined interventions may leads to higher proportion of participants returning to work in the short term (up… compared with usual care (low certainty).

1 finding from 1 review

Physical conditioning interventions vs usual care

Proportion of participants returning to work in the short term (up to 6 months) · patients with coronary heart disease

It is very uncertain whether physical conditioning interventions changes proportion of participants returning to work in the short term (up… compared with usual care (very low certainty).

1 finding from 1 review

Intravenous soya oil‐derived (n‐6) fatty acid‐based lipid emulsion vs intravenous fish oil‐derived (n‐3) fatty acid‐based lipid emulsion

Proportion of participants achieving clear or almost clear skin (PASI 90 to 100 or PGA 0 to 1) · guttate psoriasis

The review found no eligible studies for this question.

1 finding from 1 review

ECT plus standard care vs sham‐ECT plus standard care

Service use (short term) ‐ hospitalisation (number readmitted) · people with treatment‐resistant schizophrenia

ECT plus standard care may leads to lower service use (short term) ‐ hospitalisation (number readmitted) compared with sham‐ECT plus standard care (low certainty).

1 finding from 1 review

Aspirin plus antipsychotics vs placebo/no adjunctive treatment + antipsychotics

Behaviour: Leaving the study early (short‐term) · patients with schizophrenia

It is very uncertain whether aspirin plus antipsychotics changes leaving the study early: short‐term – for any reason compared with placebo plus antipsychotics (very low certainty).

1 finding from 1 review

Group A: amino acids vs placebo

Adverse effects: suicidal thoughts (events) · people in the prodromal stage of psychosis

It is very uncertain whether group A: amino acids changes adverse effects: suicidal thoughts Short‐term (events) compared with placebo (very low certainty).

1 finding from 1 review