Cochrane · systematic review · CD011847
Electroconvulsive therapy for treatment‐resistant schizophrenia
Sinclair, DJM, Zhao, S, Qi, F, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
SchizophreniaAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
28
current version
GRADE rated
11
No studies
17
Included studies
NR
No studies 17 · 60.7%Ungraded 0 · 0%Very low 7 · 25%Low 3 · 10.7%Moderate 1 · 3.6%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
ECT plus standard care versus sham‐ECT plus standard care for treatment‐resistant schizophrenia
Population: people with treatment‐resistant schizophrenia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Response to treatment Clinically important response to treatment as defined by each study ECT plus standard care vs sham‐ECT plus standard care | no estimate extracted | NR | No studies |
Cognitive functioning Clinically important change in cognitive functioning as defined by each study ECT plus standard care vs sham‐ECT plus standard care | no estimate extracted | NR | No studies |
Satisfaction and acceptability of treatment ‐ leaving the study early ECT plus standard care vs sham‐ECT plus standard care | no estimate extracted | NR | No studies |
Mental state (short term) ‐ total scores (BPRS, high = poor) ECT plus standard care vs sham‐ECT plus standard care | no estimate extracted | 1 study · 25 participants | Very low Downgraded: imprecision, indirectness |
General functioning Clinically important change in general functioning as defined by each study ECT plus standard care vs sham‐ECT plus standard care | no estimate extracted | NR | No studies |
Service use (short term) ‐ hospitalisation (number readmitted) ECT plus standard care vs sham‐ECT plus standard care | RR 0.29 [0.1, 0.85] | 1 study · 25 participants | Low Downgraded: imprecision |
Adverse event/effect(s) ‐ death ECT plus standard care vs sham‐ECT plus standard care | no estimate extracted | NR | No studies |
ECT plus standard care versus antipsychotics plus standard care for treatment‐resistant schizophrenia
Population: people with treatment‐resistant schizophrenia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Response to treatment (medium term) Clinically important response to treatment as defined by each study ECT plus standard care vs antipsychotics plus standard care | RR 1.23 [0.95, 1.58] | 1 study · 162 participants | Low Downgraded: risk of bias, imprecision |
Cognitive functioning Clinically important change in cognitive functioning as defined by each study ECT plus standard care vs antipsychotics plus standard care | no estimate extracted | NR | No studies |
Satisfaction and acceptability of treatment ‐ leaving the study early ECT plus standard care vs antipsychotics plus standard care | no estimate extracted | NR | No studies |
Mental state (short term) ‐ total scores (BPRS, high = poor) ECT plus standard care vs antipsychotics plus standard care | no estimate extracted | 1 study · 162 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
General functioning Clinically important change in general functioning as defined by each study ECT plus standard care vs antipsychotics plus standard care | no estimate extracted | NR | No studies |
Service use ‐ hospitalisation ECT plus standard care vs antipsychotics plus standard care | no estimate extracted | NR | No studies |
Adverse event/effect(s) ‐ death ECT plus standard care vs antipsychotics plus standard care | no estimate extracted | NR | No studies |
ECT plus standard care versus standard care for treatment‐resistant schizophrenia
Population: people with treatment‐resistant schizophrenia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Response to treatment (medium term) Clinically important response to treatment as defined by each study ECT plus standard care vs standard care | RR 2.06 [1.75, 2.42] | 9 studies · 819 participants | Moderate Downgraded: risk of bias |
Cognitive functioning (short term) ‐ memory deterioration ECT plus standard care vs standard care | RR 27 [1.67, 437.68] | 1 study · 72 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Satisfaction and acceptability of treatment (medium term) ‐ leaving the study early ECT plus standard care vs standard care | RR 1.18 [0.38, 3.63] | 3 studies · 354 participants | Very low Downgraded: risk of bias, imprecision |
Mental state (medium term) ‐ total scores (BPRS, high = poor) ECT plus standard care vs standard care | no estimate extracted | 2 studies · 345 participants | Low Downgraded: risk of bias, indirectness |
General functioning (medium term) ‐ average scores (GAF, high = good) ECT plus standard care vs standard care | no estimate extracted | 2 studies · 97 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Service use ‐ hospitalisation ECT plus standard care vs standard care | no estimate extracted | NR | No studies |
Adverse event/effect(s) ‐ death ECT plus standard care vs standard care | no estimate extracted | NR | No studies |
ECT alone versus antipsychotics for treatment‐resistant schizophrenia
Population: people with treatment‐resistant schizophrenia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Response to treatment Clinically significant response to treatment as defined by each study ECT alone vs antipsychotics | no estimate extracted | NR | No studies |
Cognitive functioning Clinically important change in cognitive functioning as defined by each study ECT alone vs antipsychotics | no estimate extracted | NR | No studies |
Satisfaction and acceptability of treatment ‐ leaving the study early ECT alone vs antipsychotics | no estimate extracted | NR | No studies |
Mental state (medium term) ‐ total scores (BPRS, high = poor) ECT alone vs antipsychotics | no estimate extracted | 1 study · 30 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
General functioning (medium term) ‐ average scores (GAF, high = good) ECT alone vs antipsychotics | no estimate extracted | 1 study · 30 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Service use ‐ hospitalisation ECT alone vs antipsychotics | no estimate extracted | NR | No studies |
Adverse event/effect(s) ‐ death ECT alone vs antipsychotics | no estimate extracted | NR | No studies |