Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,340 questions · 1,512 findings · 205 reviews

No studies found 317 · 21%GRADE not reported 358 · 23.7%Very low 356 · 23.5%Low 271 · 17.9%Moderate 173 · 11.4%High 37 · 2.4%

Glucosamine sulfate (oral) vs ibuprofen

Maximum voluntary jaw opening (mm), change from baseline · Adults (>18 years) with temporomandibular joint osteoarthritis (TMJ OA) diagnosed by RDC/TMD or compatible criteria

Glucosamine sulfate (oral) showed no clear difference in maximum voluntary jaw opening (mm), change from baseline compared with ibuprofen (oral); GRADE not reported.

1 finding from 1 review

Intra-articular injection of sodium hyaluronate vs corticosteroid injection

Extent of mandibular movement (maximum jaw opening, lateral and contralateral movement, jaw protrusion) · Adults (>18 years) with temporomandibular joint osteoarthritis (TMJ OA) diagnosed by RDC/TMD or compatible criteria

Intra-articular injection of sodium hyaluronate showed no clear difference in extent of mandibular movement (maximum jaw opening, lateral and… compared with intra-articular injection of corticosteroids (betamethasone); GRADE not reported.

1 finding from 1 review
  • Interventions for managing temporomandibular joint osteoarthritis 2012 · Cochrane All outcomes
    14 days to 6 months
    None of the mean differences between interventions for the measures of jaw movements (maximum jaw opening, lateral movement to affected side, contralateral movement, jaw protrusion; Analyses 1.16-1.27) showed…
    1 study · 40 participants
    GRADE not reported

Intervention not reported

Episodes of febrile neutropenia · patients with prevention and treatment of infectious complications in patients with acute myelogenous leukemia

The intervention showed no clear difference in episodes of febrile neutropenia (moderate certainty).

1 finding from 1 review

Glucosamine sulfate (oral) vs ibuprofen

Pain-free maximum jaw opening (mm), change from baseline · Adults (>18 years) with temporomandibular joint osteoarthritis (TMJ OA) diagnosed by RDC/TMD or compatible criteria

Glucosamine sulfate (oral) showed no clear difference in pain-free maximum jaw opening (mm), change from baseline compared with ibuprofen (oral); GRADE not reported.

1 finding from 1 review

Arthroscopy vs Arthrocentesis

Maximal mouth opening (interincisal distance) · Adults (older than 18 years) with a temporomandibular disorder (synovitis, disc displacement with or without reduction, myofascial…

Arthroscopy led to higher maximum interincisal opening (mm) after 12 months compared with arthrocentesis; GRADE not reported.

1 finding from 1 review

Radioisotopes vs placebo

Safety (AE, adverse drug reaction): thrombocytopenia Grades 3 or 4 according to National Cancer Institute · patients with metastatic bone pain

Radioisotopes showed no clear difference in thrombocytopenia III‐IV compared with placebo (low certainty).

1 finding from 1 review

Radioisotopes vs placebo

Leucocytopenia III‐IV · patients with metastatic bone pain

Radioisotopes may leads to higher leucocytopenia III‐IV compared with placebo (low certainty).

1 finding from 1 review

Intervention not reported

Average reduction in mean speed 2.3 km/h (p = 0.05) at camera sites post 1st year. Average reduction in mean speeds 1.3 km/h (‐2.6 to 0.1)post 2nd year on experimental open roads
1 finding from 1 review

Intervention not reported

Over the first 2 years of the study mean speeds fell by 1.3 km/h (‐2.6 to 0.1) and 85th percentile speeds reduced by 4.3 km/h on open roads generally,compared with the rest of the country.
1 finding from 1 review

Intervention not reported

Having controlled for season and general trends, injury crash outcomes in experimental areas relative to control areas were a net reduction of 11% (p= 0.03) in all crashes and 19% (p=0.002) in injury crashes on open roads across the region associa...

The review found no eligible studies for this question.

1 finding from 1 review

Arthrocentesis and lavage vs Arthroscopy

Trismus / maximum mouth opening (mean) · Adults with temporomandibular joint disorders (internal derangement; anterior disc displacement with or without reduction) whose symptoms…

Arthrocentesis and lavage led to lower maximum incisal (mouth) opening (MIO) compared with arthroscopy; GRADE not reported.

1 finding from 1 review

Occlusal splint vs Transcutaneous electric nerve stimulation (TENS)

Clicks in TMJ on oral opening and closing · People with sleep bruxism (tooth grinding or clenching); children (greater than 1 year old) and adults; diagnosis clinical,…

Occlusal splint showed no clear difference in clicks in TMJ on oral opening and closing compared with transcutaneous electric nerve stimulation (TENS); GRADE not reported.

2 findings from 1 review