Cochrane · systematic review · CD008909
Anthracycline‐containing regimens for treatment of follicular lymphoma in adults
Itchaki, G, Gafter‐Gvili, A, Lahav, M, et al. · Cochrane Database of Systematic Reviews · 2013 · Cochrane Library
HaematologyAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 2 · 28.6%Low 0 · 0%Moderate 3 · 42.9%High 2 · 28.6%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
ACR compared to non‐ACR for treatment of follicular lymphoma in adults
Population: adults receiving treatment for follicular lymphoma
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Overall survival number of dead patients ACR vs non‐ACR | HR 0.99 [0.77, 1.29] | 3 studies · 464 participants | Moderate Downgraded: imprecision |
Mortality at 3 years ACR vs non‐ACR | RR 0.92 [0.67, 1.26] | 3 studies · 465 participants | Moderate Downgraded: imprecision |
Overall response ACR vs non‐ACR | RR 1.06 [1, 1.12] | 3 studies · 622 participants | Moderate Downgraded: inconsistency |
Disease control number of patients with progression ACR vs non‐ACR | HR 0.65 [0.52, 0.81] | 4 studies · 759 participants | High |
Progression/relapse at 3 years ACR vs non‐ACR | RR 0.73 [0.63, 0.85] | 4 studies · 724 participants | High |
Neutropenia grade 3‐4 ACR vs non‐ACR | RR 1.94 [1.46, 2.56] | 2 studies · 533 participants | Very low Downgraded: imprecision, inconsistency |
Cardiotoxicity** ACR vs non‐ACR | RR 4.55 [0.92, 22.49] | 3 studies · 1412 participants | Very low Downgraded: imprecision |