Clinical failure—different beta lactam Antibiotic modifications · patients with sepsis
It is very uncertain whether monotherapy changes clinical failure—different beta lactam Antibiotic modifications compared with combination therapy compared (very low certainty).
1 finding from 1 review
All cause mortality · people with cancer who have febrile neutropenia
beta‐lactam monotherapy showed no clear difference in all cause mortality compared with beta‐lactam‐aminoglycoside combination therapy (high certainty).
1 finding from 1 review
Any nephrotoxicity ‐ Ag dosing regimen (Copy) · people with cancer who have febrile neutropenia
beta‐lactam monotherapy leads to lower any nephrotoxicity ‐ Ag dosing regimen (Copy) compared with beta‐lactam‐aminoglycoside combination therapy (high certainty).
1 finding from 1 review
Clinical failure—same beta lactam Antibiotic modifications · people with cancer who have febrile neutropenia
beta‐lactam monotherapy probably leads to higher treatment failure ‐ same beta‐lactam compared with beta‐lactam‐aminoglycoside combination therapy (moderate certainty).
1 finding from 1 review
Treatment failure ‐ different beta‐lactam · people with cancer who have febrile neutropenia
beta‐lactam monotherapy may leads to lower treatment failure ‐ different beta‐lactam compared with beta‐lactam‐aminoglycoside combination therapy (low certainty).
1 finding from 1 review
Smoking abstinence at longest · people who smoke
Varenicline showed no clear difference in smoking abstinence at longest compared with combination nicotine replacement therapy (low certainty).
1 finding from 1 review
SAEs · people who smoke
Varenicline showed no clear difference in SAEs compared with combination nicotine replacement therapy (low certainty).
1 finding from 1 review
Neuropsychiatric SAEs · people who smoke
Varenicline showed no clear difference in neuropsychiatric SAEs compared with combination nicotine replacement therapy (low certainty).
1 finding from 1 review
Cardiac SAEs · people who smoke
Varenicline showed no clear difference in cardiac SAEs compared with combination nicotine replacement therapy (low certainty).
1 finding from 1 review
Overall survival (OS) · platinum‐sensitive recurrent EOC
Summary of findings 1: PLD with chemotherapy showed no clear difference in overall survival (OS) compared with alternative combination chemotherapy (moderate certainty).
1 finding from 1 review
Progression‐free survival · platinum‐sensitive recurrent EOC
Summary of findings 1: PLD with chemotherapy probably leads to lower progression‐free survival (PFS) compared with alternative combination chemotherapy (moderate certainty).
1 finding from 1 review
QoL · platinum‐sensitive recurrent EOC
1 finding from 1 review
Adverse events (grade ≥ 3) · platinum‐sensitive recurrent EOC
Summary of findings 1: PLD with chemotherapy showed no clear difference in overall severe adverse events (grade ≥ 3) compared with alternative combination chemotherapy (moderate certainty).
1 finding from 1 review
Anaemia (grade ≥ 3) · platinum‐sensitive recurrent EOC
Summary of findings 1: PLD with chemotherapy probably leads to higher anaemia (grade ≥ 3) compared with alternative combination chemotherapy (moderate certainty).
1 finding from 1 review
Hand‐foot syndrome (grade ≥ 3) · platinum‐sensitive recurrent EOC
It is very uncertain whether summary of findings 1: PLD with chemotherapy changes hand‐foot syndrome (grade ≥ 3) compared with alternative combination chemotherapy (very low certainty).
1 finding from 1 review
Neurological (grade ≥ 3) · platinum‐sensitive recurrent EOC
It is very uncertain whether summary of findings 1: PLD with chemotherapy changes neurological (grade ≥ 3) compared with alternative combination chemotherapy (very low certainty).
1 finding from 1 review
Breakthrough pain · term, pregnant women (nulliparous, or combination of nulli‐ and muliparous) requesting for labour epidural analgesia
Automated mandatory bolus probably leads to lower breakthrough pain compared with basal infusion (moderate certainty).
1 finding from 1 review
Caesarean delivery during labour epidural analgesia · term, pregnant women (nulliparous, or combination of nulli‐ and muliparous) requesting for labour epidural analgesia
Automated mandatory bolus showed no clear difference in caesarean delivery during labour epidural analgesia compared with basal infusion (moderate certainty).
1 finding from 1 review
Instrumental delivery during labour epidural analgesia · term, pregnant women (nulliparous, or combination of nulli‐ and muliparous) requesting for labour epidural analgesia
Automated mandatory bolus showed no clear difference in instrumental delivery during labour epidural analgesia compared with basal infusion (moderate certainty).
1 finding from 1 review
Duration of labour analgesia in minutes · term, pregnant women (nulliparous, or combination of nulli‐ and muliparous) requesting for labour epidural analgesia
1 finding from 1 review