Monotherapy vs combination therapy compared: Clinical failure—different beta lactam Antibiotic modifications
It is very uncertain whether monotherapy changes clinical failure—different beta lactam Antibiotic modifications compared with combination therapy compared (very low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Monotherapy vs combination therapy compared Clinical failure—different beta lactam Antibiotic modifications · participants with sepsis It is very uncertain whether monotherapy changes clinical failure—different beta lactam Antibiotic modifications compared with combination therapy compared (very low certainty). Beta lactam antibiotic monotherapy versus beta lactam‐aminoglycoside antibiotic combination therapy for sepsis (2014) · Cochrane Headline outcomes only | RR 0.75 [0.67, 0.84] | 46 studies · 4933 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Beta lactam antibiotic monotherapy versus beta lactam‐aminoglycoside antibiotic combination therapy for sepsis 2014 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.