Cochrane · systematic review · CD003344
Beta lactam antibiotic monotherapy versus beta lactam‐aminoglycoside antibiotic combination therapy for sepsis
Paul, M, Lador, A, Grozinsky‐Glasberg, S, et al. · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
Emergency and Critical CareAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
4
current version
GRADE rated
4
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 2 · 50%Low 2 · 50%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Monotherapy versus combination therapy compared for sepsis
Population: participants with sepsis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality—same beta lactam Survival Monotherapy vs combination therapy compared | RR 0.97 [0.73, 1.3] | 13 studies · 1431 participants | Low Downgraded: publication bias |
All‐cause mortality—different beta lactam Monotherapy vs combination therapy compared | RR 0.85 [0.71, 1.01] | 31 studies · 4146 participants | Low Downgraded: risk of bias, publication bias |
Clinical failure—same beta lactam Antibiotic modifications Monotherapy vs combination therapy compared | RR 1.11 [0.95, 1.29] | 20 studies · 1870 participants | Very low |
Clinical failure—different beta lactam Antibiotic modifications Monotherapy vs combination therapy compared | RR 0.75 [0.67, 0.84] | 46 studies · 4933 participants | Very low |