beta‐lactam monotherapy vs beta‐lactam (cloxacillin) plus aminoglycoside (gentamicin): Clinical failure—same beta lactam Antibiotic modifications
beta‐lactam monotherapy probably leads to higher treatment failure ‐ same beta‐lactam compared with beta‐lactam‐aminoglycoside combination therapy (moderate certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
beta‐lactam monotherapy vs beta‐lactam‐aminoglycoside combination therapy Treatment failure ‐ same beta‐lactam · febrile neutropenic cancer patients. beta‐lactam monotherapy probably leads to higher treatment failure ‐ same beta‐lactam compared with beta‐lactam‐aminoglycoside combination therapy (moderate certainty). Beta‐lactam versus beta‐lactam‐aminoglycoside combination therapy in cancer patients with neutropenia (2013) · Cochrane Headline outcomes only | RR 1.11 [1.02, 1.2] | 16 studies · 2833 participants | Moderate |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Beta‐lactam versus beta‐lactam‐aminoglycoside combination therapy in cancer patients with neutropenia 2013 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.