Bleeding Index (BI) · Individuals assessed for periodontal health (mainly children and adolescents, age >2 years)
Bleeding index is significantly higher in persons with orofacial cleft than in healthy controls (p<0.0001), but no pooled effect size was reported (ungraded).
1 finding from 1 review
Oral microbiota composition · Individuals assessed for oral microbiota (mainly children and adolescents)
Oral microbiota composition differs between persons with orofacial cleft and healthy controls, synthesized qualitatively across 8 studies but not meta-analyzed (ungraded).
1 finding from 1 review
no estimate extracted
8 studies
GRADE not reported
Radiographic proximal caries lesion progression · Children and adults with non-cavitated proximal (interproximal) caries lesions in primary and/or permanent teeth (ages 3-45)
No eligible studies compared microinvasive techniques with invasive (restorative) treatment; this planned comparison had zero included studies.
1 finding from 1 review
Early childhood caries (ECC) · Children aged 0-5 years in North Africa
Male children had higher odds of ECC (OR 2.911).
1 finding from 1 review
OR 2.911 [1.42, 5.99]
1 study
GRADE not reported
Hip Fracture · general population
Overall hip-fracture risk showed little association with drinking-water fluoride and a nearly flat dose-response curve (narrow CI); no numeric RR reported in text; ungraded.
1 finding from 1 review
Intervention not reported
Composite: Preference for replacement over repair - Scenario 7: non-stable (mobile) restoration
The intervention led to higher composite: Preference for replacement over repair - Scenario 7:…; GRADE not reported.
1 finding from 1 review
RR 8.67 [5.32, 14.13]
11 studies
GRADE not reported
Caries in primary teeth: dmft (3 years) · Children and adolescents with epilepsy
The review found no statistically significant difference in dmft among children or adolescents.
1 finding from 1 review
Intervention not reported
Composite: Preference for replacement over repair - Scenario 3: secondary caries
The intervention led to higher composite: Preference for replacement over repair - Scenario 3:…; GRADE not reported.
1 finding from 1 review
RR 2.28 [1.69, 3.08]
Studies not reported
GRADE not reported
Intervention not reported
Amalgam: Preference for replacement over repair - Scenario 5: open margin
The intervention led to higher amalgam: Preference for replacement over repair - Scenario 5: open…; GRADE not reported.
1 finding from 1 review
RR 6.16 [5.32, 7.14]
7 studies
GRADE not reported
Incidence of proximal (interdental) caries lesions from bitewing radiographs · Orthodontic patients (any age) undergoing orthodontic treatment (mostly fixed appliances)
Only one included study assessed proximal caries incidence from bitewing radiographs; it was not included in the meta-analysis and no pooled estimate is available (ungraded).
1 finding from 1 review
Periodontal inflamed surface area (PISA) · adults
Patients with lacunar stroke had a larger periodontal inflamed surface area than those without (MD 849.92); ungraded, no heterogeneity.
1 finding from 1 review
Intervention not reported
Amalgam: Preference for replacement over repair - Scenario 4: marginal discoloration
The intervention led to higher amalgam: Preference for replacement over repair - Scenario 4:…; GRADE not reported.
1 finding from 1 review
RR 6.88 [4.77, 9.92]
6 studies
GRADE not reported
Serum ferritin (ng/mL) · Children or adolescents
Serum ferritin tends to be lower in children with dental caries, but the pooled difference is not statistically significant (MD -3.96, 95% CI -8.48 to 0.57; very low certainty).
1 finding from 1 review
Intervention not reported
Composite: Preference for replacement over repair - Scenario 4: marginal discoloration
The intervention showed no clear difference in composite: Preference for replacement over repair - Scenario 4:…; GRADE not reported.
1 finding from 1 review
RR 1.44 [0.71, 2.91]
2 studies
GRADE not reported
Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)
In the Self-Etch adhesive + chemical ACAD protocol network, HAp vs Silica showed no significant difference in 24 h bond strength (MD -3.756, 95% CI -10.536 to 3.024; Moderate certainty).
1 finding from 1 review
Oral health-related quality of life · people aged 60 years and older living in the community
Lower out-of-pocket health expenditure was associated with better OHRQoL (83.9, 95% CI 75.2 to 92.6 vs 67.5, 95% CI 58.5 to 76.5); the difference was statistically significant (ungraded).
2 findings from 1 review
MEAN 67.5 [58.5, 76.5]
Studies not reported
GRADE not reported
MEAN 83.9 [75.2, 92.6]
Studies not reported
GRADE not reported
Intervention not reported
Amalgam: Preference for replacement over repair - Scenario 8: disruption of occlusal integrity
The intervention showed no clear difference in amalgam: Preference for replacement over repair - Scenario 8:…; GRADE not reported.
1 finding from 1 review
RR 2.12 [0.66, 6.82]
2 studies
GRADE not reported
Early childhood caries (ECC) · Children aged 0-5 years in North Africa
A history of dental visits was associated with higher odds of ECC (OR 2.444).
1 finding from 1 review
OR 2.444 [1.108, 2.072]
1 study
GRADE not reported
Plaque · Patients with cleft lip and palate (CLP)
Plaque index does not differ significantly between unilateral and bilateral cleft lip and palate (MD -0.13, 95% CI -0.38 to 0.12; ungraded).
1 finding from 1 review
Lacunar stroke · European-ancestry adults
Genetically predicted pulp and periapical diseases were associated with modestly higher odds of lacunar stroke (OR 1.20); ungraded MR, FDR-adjusted P 0.033.
1 finding from 1 review
OR 1.20 [1.03, 1.41]
Studies not reported
GRADE not reported