Question · asked by 1 review
Cleft lip and/or palate (CL/P) vs Healthy controls without cleft: Oral microbiota composition
- Population
- Individuals assessed for oral microbiota (mainly children and adolescents)
- Intervention
- Cleft lip and/or palate (CL/P)
- Comparison
- Healthy controls without cleft
- Outcome
- Oral microbiota composition
Oral microbiota composition differs between persons with orofacial cleft and healthy controls, synthesized qualitatively across 8 studies but not meta-analyzed (ungraded).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Orofacial cleft (cleft lip and/or palate) as exposure vs Healthy controls without cleft Oral microbiota composition · Individuals assessed for oral microbiota (mainly children and adolescents) · Clinical oral/salivary microbial sampling; various countries Oral microbiota composition differs between persons with orofacial cleft and healthy controls, synthesized qualitatively across 8 studies but not meta-analyzed (ungraded). Oral health in patients with cleft lip and palate: a systematic literature review and meta-analysis of… (2025) All outcomes | no estimate extracted | 8 studies | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Oral health in patients with cleft lip and palate: a systematic literature review and meta-analysis of periodontal and dental disease and… 2025 All outcomes | March 2023 to January 2024 | 30 | Not applicable |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.