Non-Cochrane · aetiology · PM40379944
The contribution of oral infectious diseases in lacunar stroke based on meta-analysis and Mendelian randomization study.
Zheng Qifan, Xu Tong, Luo Shiyin, et al. · Scientific reports · 2025 · PubMed · doi:10.1038/s41598-025-99742-x
Full textEvery question was extracted from the full text, figures and supplements by two independent LLM extractors, disagreements adjudicated. Rows cite where in the review the value comes from.
Questions
11
current version
GRADE rated
0
No studies
2
Included studies
10
linked below
No studies 2 · 18.2%Ungraded 9 · 81.8%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Adults | Adults; 5 cross-sectional studies from Japan and Republic of Chile (sample sizes 110 to 370); MR used European-ancestry GWAS (n=5 included studies) |
| Intervention | Oral infectious diseases: dental caries, pulp and periapical diseases, periodontitis | Periodontitis (meta-analysis); genetically predicted periodontitis, dental caries, and pulp and periapical diseases (MR) |
| Comparison | Patients without oral infectious diseases | Individuals without periodontitis or without lacunar stroke; lower genetic liability (MR) |
| Outcomes | Lacunar stroke | Lacunar stroke; periodontal indices (probing depth, clinical attachment level, PISA, full-mouth bleeding score) |
| Study designs | Meta-analysis of cross-sectional studies; two-sample Mendelian randomization using GWAS summary data | Cross-sectional studies (n=5); two-sample Mendelian randomization |
| Timing | Not specified | Not specified (cross-sectional) |
Search date: August 2024. Databases: PubMed; Cochrane Library; EMBASE; Web of Science; Google Scholar (grey literature); EU Clinical Trials Registry
Questions and results
Periodontitis vs Without periodontitis
Population: Adults
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Lacunar stroke Individuals with periodontitis had about five times higher odds of lacunar stroke than those without periodontitis (pooled OR 5.16); ungraded cross-sectional evidence, with the caution that the three studies came from one research team. Source: Results, 'Periodontitis may serve as a potential risk factor for lacunar stroke'; Fig. 3 · same question in other reviews | OR 5.16 [3.68, 7.24] | 3 studies | Ungraded |
Lacunar stroke (cases) vs Without lacunar stroke (controls)
Population: Adults
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Periodontal inflamed surface area (PISA) Patients with lacunar stroke had a larger periodontal inflamed surface area than those without (MD 849.92); ungraded, no heterogeneity. Source: Results, 'The periodontitis surface area and the total mouth bleeding score in individuals with lacunar stroke were significantly… · same question in other reviews | MD 849.92 [698.86, 1000.98] | 2 studies | Ungraded |
Clinical attachment level (CAL) Patients with lacunar stroke had greater clinical attachment loss than those without (MD 1.34); ungraded, with substantial heterogeneity (I2 = 95%). Source: Results, 'The periodontitis surface area and the total mouth bleeding score in individuals with lacunar stroke were significantly… · same question in other reviews | MD 1.34 [0.63, 2.05] | 4 studies | Ungraded |
Periodontal probing depth (PD) Patients with lacunar stroke had greater periodontal probing depth than those without (MD 0.98); ungraded, with substantial heterogeneity (I2 = 88%). Source: Results, 'The periodontitis surface area and the total mouth bleeding score in individuals with lacunar stroke were significantly… · same question in other reviews | MD 0.98 [0.57, 1.38] | 4 studies | Ungraded |
Full-mouth bleeding score (FMBS) Patients with lacunar stroke had a higher full-mouth bleeding score than those without (MD 31.26); ungraded, no heterogeneity. Source: Results, 'The periodontitis surface area and the total mouth bleeding score in individuals with lacunar stroke were significantly… · same question in other reviews | MD 31.26 [28.82, 33.70] | 3 studies | Ungraded |
Dental caries vs Without dental caries
Population: Adults
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Lacunar stroke No eligible studies were found for the association between dental caries and lacunar stroke in the meta-analysis. Source: Results, 'Study selection' (no studies on dental caries and LS identified); Methods, 'Meta-analysis' PICO · same question in other reviews | No studies addressing the association between dental caries and LS were identified. | 0 studies | No studies |
Pulp and periapical diseases vs Without pulp and periapical diseases
Population: Adults
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Lacunar stroke No eligible studies were found for the association between pulp and periapical diseases and lacunar stroke in the meta-analysis. Source: Results, 'Study selection' (no studies on pulp and periapical diseases and LS identified); Methods, 'Meta-analysis' PICO · same question in other reviews | No studies addressing the association between pulp and periapical diseases and LS were identified. | 0 studies | No studies |
Genetically predicted periodontitis vs Without periodontitis (lower genetic liability)
Population: European-ancestry adults (GWAS)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Lacunar stroke Genetically predicted periodontitis was associated with modestly higher odds of lacunar stroke (OR 1.24); ungraded MR, though the FDR-adjusted P was 0.064 for the primary IVW-FE method (ML-adjusted P 0.037). Source: Results, 'Periodontitis and diseases of the pulp and periapical tissues may pose potential risk factors for lacunar stroke'; Fig. 5;… · same question in other reviews | OR 1.24 [1.03, 1.49] | NR | Ungraded |
Genetically predicted pulp and periapical diseases vs Without pulp and periapical diseases (lower genetic liability)
Population: European-ancestry adults (GWAS)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Lacunar stroke Genetically predicted pulp and periapical diseases were associated with modestly higher odds of lacunar stroke (OR 1.20); ungraded MR, FDR-adjusted P 0.033. Source: Results, 'Periodontitis and diseases of the pulp and periapical tissues may pose potential risk factors for lacunar stroke'; Fig. 5;… · same question in other reviews | OR 1.20 [1.03, 1.41] | NR | Ungraded |
Genetically predicted dental caries vs Without dental caries (lower genetic liability)
Population: European-ancestry adults (GWAS)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Lacunar stroke Genetically predicted dental caries showed no significant causal association with lacunar stroke (ungraded MR). Source: Results, 'Periodontitis and diseases of the pulp and periapical tissues may pose potential risk factors for lacunar stroke' (dental… · same question in other reviews | OR 0.92 [0.69, 1.23] | NR | Ungraded |
Comparison
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Lacunar stroke Mediation via IL-1α, IL-6, TNF, CRP (two-step MR) | Indirect effect No mediating effect | NR | Ungraded |
Included primary studies 10
Open as a trial list| Study | Also included by | Outcomes it informs here | Trial PICO | Results |
|---|---|---|---|---|
| Ito 2022 Risk assessment of lacunar infarct associated with oral conditions: A case control study focused on radiographic bone loss and Eichner… DOI:10.2186/jpr.jpr_d_20_00310 | this review only | not stated | not extracted yet | not extracted yet |
| Ito 2022 Risk assessment of lacunar infarct associated with oral conditions: A case control study focused on radiographic bone loss and Eichner… PMID:34511558 | this review only | not stated | not extracted yet | not extracted yet |
| Leira 2016 Chronic periodontitis is associated with lacunar infarct: a case-control study. PMID:27418418 | this review only | not stated | not extracted yet | not extracted yet |
| Leira 2016 (Eur J Neurol) Chronic periodontitis is associated with lacunar infarct: a case–control study DOI:10.1111/ene.13080 | this review only | not stated | not extracted yet | not extracted yet |
| Leira 2019 Periodontitis as a risk indicator and predictor of poor outcome for lacunar infarct. PMID:30362631 | this review only | not stated | not extracted yet | not extracted yet |
| Leira 2019 Periodontitis is associated with systemic inflammation and vascular endothelial dysfunction in patients with lacunar infarct. PMID:30417380 | this review only | not stated | not extracted yet | not extracted yet |
| Leira 2019 (J Clin Periodontol) Periodontitis as a risk indicator and predictor of poor outcome for lacunar infarct DOI:10.1111/jcpe.13032 | this review only | not stated | not extracted yet | not extracted yet |
| Leira 2019 (J Periodontol) Periodontitis is associated with systemic inflammation and vascular endothelial dysfunction in patients with lacunar infarct DOI:10.1002/jper.18-0560 | this review only | not stated | not extracted yet | not extracted yet |
| Taguchi 2013 Association between Oral Health and the Risk of Lacunar Infarction in Japanese Adults DOI:10.1159/000353707 | this review only | not stated | not extracted yet | not extracted yet |
| Taguchi 2013 Association between oral health and the risk of lacunar infarction in Japanese adults. PMID:23942139 | this review only | not stated | not extracted yet | not extracted yet |