Golimumab 50 mg every 4 weeks + MTX leads to higher ACR50 compared with placebo + MTX (high certainty).
MTX combination showed no clear difference in ACR 50 response of DMARDs naive patients Number of responders compared with MTX monotherapy (low certainty).
MTX combination probably leads to higher ACR 50 response of MTX inadequate responders number of responders compared with MTX monotherapy (moderate certainty).
MTX combination showed no clear difference in ACR 50 response of non‐MTX DMARDs inadequate responders number of… compared with MTX monotherapy (moderate certainty).
It is very uncertain whether MTX combination changes withdrawal due to adverse reactions (Pooled across regimens) number… compared with MTX monotherapy (very low certainty).
Abatacept (2 and 10mg/kg) + DMARDs/biologic probably leads to higher ACR 50% improvement compared with placebo + DMARDs/biologic (moderate certainty).
Summary of findings: leflunomide leads to higher ACR 50 response at 6 months compared with placebo, 6 months (high certainty).
Summary of findings: leflunomide + methotrexate leads to higher ACR 50 at 6 months compared with methotrexate, 6 months (high certainty).
Induction of labour showed no clear difference in caesarean section compared with expectant management (moderate certainty).
Induction of labour showed no clear difference in instrumental delivery compared with expectant management (low certainty).
Induction of labour probably leads to lower shoulder dystocia compared with expectant management (moderate certainty).
Induction of labour showed no clear difference in brachial plexus injury compared with expectant management (low certainty).
Induction of labour leads to lower fracture (any) compared with expectant management (high certainty).
Induction of labour showed no clear difference in low Apgar score (5 minutes) compared with expectant management (low certainty).
Induction of labour showed no clear difference in low arterial cord blood pH (< 7.10) compared with expectant management (moderate certainty).
Endovascular therapy plus conventional medical treatment probably leads to higher death or stroke compared with conventional medical treatment alone (moderate certainty).
Endovascular therapy plus conventional medical treatment probably leads to higher ipsilateral stroke compared with conventional medical treatment alone (moderate certainty).
Endovascular therapy plus conventional medical treatment showed no clear difference in type of recurrent event compared with conventional medical treatment alone (moderate certainty).
Endovascular therapy plus conventional medical treatment may leads to higher death compared with conventional medical treatment alone (low certainty).
Endovascular therapy plus conventional medical treatment showed no clear difference in dependency compared with conventional medical treatment alone (moderate certainty).