Cochrane · systematic review · CD002047
Leflunomide for the treatment of rheumatoid arthritis
Osiri, M, Shea, B, Welch, V, et al. · Cochrane Database of Systematic Reviews · 2002 · Cochrane Library
MusculoskeletalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
11
current version
GRADE rated
9
No studies
2
Included studies
NR
No studies 2 · 18.2%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 1 · 9.1%High 8 · 72.7%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Summary of findings: leflunomide versus placebo, 6 months
Population: adult patients with rheumatoid arthritis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
For outcome Summary of findings: leflunomide vs placebo, 6 months | no estimate extracted | NR | No studies |
ACR 50 response at 6 months Summary of findings: leflunomide vs placebo, 6 months | RR 2.32 [1.32, 4.05] | 1 study · 221 participants | High |
HAQ change (0‐3 scale) Summary of findings: leflunomide vs placebo, 6 months | no estimate extracted | 3 studies · 679 participants | High |
Pain change (0‐100 mm VAS) Summary of findings: leflunomide vs placebo, 6 months | no estimate extracted | 3 studies · 724 participants | High |
Radiographic change (Change in Sharp score) Summary of findings: leflunomide vs placebo, 6 months | RR 1.23 [0.91, 1.66] | 1 study · 380 participants | High |
Withdrawals due to adverse events Summary of findings: leflunomide vs placebo, 6 months | no estimate extracted | 3 studies · 727 participants | High |
Summary of findings: leflunomide + methotrexate versus methotrexate, 6 months
Population: adult patients with rheumatoid arthritis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
For outcome Summary of findings: leflunomide + methotrexate vs methotrexate, 6 months | no estimate extracted | NR | No studies |
ACR 50 at 6 months Summary of findings: leflunomide + methotrexate vs methotrexate, 6 months | RR 4.35 [2.09, 9.03] | 1 study · 263 participants | High |
HAQ change Range of HAQ: 0‐3 scale (6 months) Summary of findings: leflunomide + methotrexate vs methotrexate, 6 months | no estimate extracted | 1 study · 263 participants | High |
Change in pain (0‐100 mm VAS) Summary of findings: leflunomide + methotrexate vs methotrexate, 6 months | no estimate extracted | 1 study · 263 participants | High |
Withdrawals due to adverse events (6 months) Summary of findings: leflunomide + methotrexate vs methotrexate, 6 months | no estimate extracted | 1 study · 263 participants | Moderate |