Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

611 questions · 621 findings · 112 reviews

No studies found 53 · 8.5%GRADE not reported 70 · 11.3%Very low 91 · 14.7%Low 216 · 34.8%Moderate 152 · 24.5%High 39 · 6.3%

Plastic wrap or bag vs usual care

Hypothermia on admission to NICU: core body temperature < 36.5°C or skin temperature < 36°C · preterm or low birth weight infants

Plastic wrap or bag probably leads to lower hypothermia on admission to NICU: core body temperature < 36.5°C or… compared with routine care (moderate certainty).

1 finding from 1 review

Plastic wrap or bag vs usual care

Hyperthermia on admission to NICU: core body temperature > 37.5°C · preterm or low birth weight infants

Plastic wrap or bag probably leads to higher hyperthermia on admission to NICU: core body temperature > 37.5°C compared with routine care (moderate certainty).

1 finding from 1 review

Plastic wrap or bag vs usual care

Mortality (death within hospital stay or at 6 months' corrected gestation) · preterm or low birth weight infants

Plastic wrap or bag showed no clear difference in mortality (death within hospital stay or at 6 months' corrected… compared with routine care (moderate certainty).

1 finding from 1 review

Early inhaled steroids (< 2 weeks) vs placebo (among all randomised)

Oxygen requirement at 36 weeks' postmenstrual age · very low birth weight preterm neonates

Early inhaled steroids (< 2 weeks) showed no clear difference in CLD at 36 weeks' PMA oxygen dependency at 36 weeks' PMA compared with placebo (among all randomised) (moderate certainty).

1 finding from 1 review

Early inhaled steroids (< 2 weeks) vs placebo (among all randomised)

Death by, or CLD at, 36 weeks' PMA Death or oxygen dependency at 36 weeks' PMA · very low birth weight preterm neonates

Early inhaled steroids (< 2 weeks) probably leads to lower death by, or CLD at, 36 weeks' PMA Death or oxygen dependency at 36… compared with placebo (among all randomised) (moderate certainty).

1 finding from 1 review

Early inhaled steroids (< 2 weeks) vs placebo (among survivors)

CLD at 36 weeks' PMA · very low birth weight preterm neonates

Early inhaled steroid (< 2 weeks) probably leads to lower CLD at 36 weeks' PMA compared with placebo (among survivors) (moderate certainty).

1 finding from 1 review

Summary of findings table for oral immunoglobulin vs control

Definite necrotizing enterocolitis (NEC) during study period · preventing necrotizing enterocolitis in preterm and low birth weight neonates

Summary of findings table for oral immunoglobulin showed no clear difference in definite necrotizing enterocolitis (NEC) during study period compared with control (low certainty).

1 finding from 1 review

Summary of findings table for oral immunoglobulin vs control

Definite necrotizing enterocolitis (NEC) during study period ‐ IgA/IgG · preventing necrotizing enterocolitis in preterm and low birth weight neonates

It is very uncertain whether summary of findings table for oral immunoglobulin changes definite necrotizing enterocolitis (NEC) during study period ‐ IgA/IgG compared with control (very low certainty).

1 finding from 1 review

Summary of findings table for oral immunoglobulin vs control

Definite necrotizing enterocolitis (NEC) during study period ‐ IgG · preventing necrotizing enterocolitis in preterm and low birth weight neonates

Summary of findings table for oral immunoglobulin showed no clear difference in definite necrotizing enterocolitis (NEC) during study period ‐ IgG compared with control (low certainty).

1 finding from 1 review

Summary of findings table for oral immunoglobulin vs control

Definite NEC after study period · preventing necrotizing enterocolitis in preterm and low birth weight neonates

It is very uncertain whether summary of findings table for oral immunoglobulin changes definite NEC after study period compared with control (very low certainty).

1 finding from 1 review

Summary of findings table for oral immunoglobulin vs control

NEC‐related surgery during study period · preventing necrotizing enterocolitis in preterm and low birth weight neonates

It is very uncertain whether summary of findings table for oral immunoglobulin changes NEC‐related surgery during study period compared with control (very low certainty).

1 finding from 1 review