Findings

What do systematic reviews say?

747 questions · 815 findings · 144 reviews

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No studies found 154 · 18.9%GRADE not reported 147 · 18%Very low 164 · 20.1%Low 199 · 24.4%Moderate 121 · 14.8%High 30 · 3.7%

Intervention not reported

Pain Acroparaesthesia and Fabry crises · Anderson‐Fabry disease

The review found no eligible studies for this question.

1 finding from 1 review

Enzyme replacement therapy for Anderson‐Fabry disease 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Cocaine use assessed by the mean (SD) proportion of cocaine‐free urinalysis across the study per participant · people with cocaine dependence

1 finding from 1 review

Psychostimulant drugs for cocaine dependence 2016 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 526 participants
Very low

Intervention not reported

Intracranial pressure (ICP) within the treatment period · people with acute TBI secondary to head injury

1 finding from 1 review

Progesterone for acute traumatic brain injury 2016 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 3 participants
GRADE not reported

Short‐acting insulin analogues vs regular human insulin

Macrovascular complications

The review found no eligible studies for this question.

1 finding from 1 review

Short‐acting insulin analogues versus regular human insulin for adults with type 1 diabetes mellitus 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Initiation of water fluoridation (artificial or natural) vs Low/non-fluoridated water (0.4 ppm fluoride or less)

Disparities in caries across socioeconomic status (SES) · People of all ages in a community setting; the included caries studies were all in children aged 3 to 16 years

1 finding from 1 review

Water fluoridation for the prevention of dental caries 2015 · Cochrane All outcomes
There is insufficient information to determine whether initiation of a water fluoridation programme results in a change in disparities in caries levels across SES. Data from 3 observational studies (participants not…
3 studies · 35399 participants
Low

Intervention not reported

Progressive intracranial haemorrhage · Treating patients with traumatic brain injury

The intervention leads to lower progressive intracranial haemorrhage (high certainty).

1 finding from 1 review

Antifibrinolytic drugs for acute traumatic injury 2015 · Cochrane Headline outcomes only
RR 0.75 [0.58, 0.98]
2 studies · 478 participants
High

All diet and/or exercise interventions vs (Optimised) usual care

Macrosomia Infant birthweight > 4000 g · pregnant women

All diet and/or exercise interventions showed no clear difference in macrosomia Infant birthweight > 4000 g compared with standard/other care (high certainty).

1 finding from 1 review

Diet or exercise, or both, for preventing excessive weight gain in pregnancy 2015 · Cochrane Headline outcomes only
RR 0.93 [0.86, 1.02]
27 studies · 8598 participants
High

Liberal vs restrictive transfusion protocols

Inability to walk 10 feet (3 m; or across a room) without human assistance · Patients with hip fracture repair

Liberal showed no clear difference in inability to walk 10 feet (3 m; or across a room) without human… compared with restrictive threshold transfusion (low certainty).

1 finding from 1 review

Red blood cell transfusion for people undergoing hip fracture surgery 2015 · Cochrane Headline outcomes only
RR 1 [0.87, 1.15]
2 studies · 2083 participants
Low

Cessation of water fluoridation (fluoride removed from the water supply) vs Continued fluoridated water

Disparities in caries across socioeconomic status (SES) · People of all ages in a previously fluoridated community (Maupome 2001: children with generally low caries experience)

The review found no eligible studies for this question.

1 finding from 1 review

Water fluoridation for the prevention of dental caries 2015 · Cochrane All outcomes
No evidence to determine the effect of the cessation of water fluoridation on disparities in caries across SES.
0 studies
No studies found

Intervention not reported

ACR 50 American College of Rheumatology improvement criteria · patients with rheumatoid arthritis

The intervention probably leads to higher ACR 50 American College of Rheumatology improvement criteria (moderate certainty).

1 finding from 1 review

Methotrexate for treating rheumatoid arthritis 2014 · Cochrane Headline outcomes only
RR 3 [1.5, 6]
1 study · 300 participants
Moderate

Thyrotropin‐releasing hormone tartrate vs placebo

Short‐term (1 week) change in isolated movement, objective and subjective measures of speech production SARA. Scale from: 0 to 6. Higher scores indicate more severe speech disorder. · people with speech disorder resulting from hereditary ataxias

1 finding from 1 review

Treatment for speech disorder in Friedreich ataxia and other hereditary ataxia syndromes 2014 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 245 participants
Very low

Intensive glycaemic control vs conventional glucose control

Macrovascular complications · persons with type 1 diabetes mellitus

1 finding from 1 review

Intensive glucose control versus conventional glucose control for type 1 diabetes mellitus 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Intervention not reported

Any intracranial disease progression at 1 year · Patients with brain metastases

The intervention may leads to lower any intracranial disease progression at 1 year (low certainty).

1 finding from 1 review

Surgery or radiosurgery plus whole brain radiotherapy versus surgery or radiosurgery alone for brain metastases 2014 · Cochrane Headline outcomes only
RR 0.46 [0.35, 0.6]
4 studies · 304 participants
Low

Interdental brushing plus toothbrushing vs Flossing plus toothbrushing

Gingivitis · Adults, 16 years and older (dentate)

Interdental brushing plus toothbrushing may leads to lower gingivitis (bleeding and gingival indices; standardised across… compared with flossing plus toothbrushing (low certainty).

2 findings from 1 review · compare the 2 reviews

Interdental brushing for the prevention and control of periodontal diseases and dental caries in adults 2013 · Cochrane All outcomes
1 month (4 to 6 weeks)
SMD -0.53 [-0.81, -0.24]
7 studies · 326 participants
Low
Interdental brushing for the prevention and control of periodontal diseases and dental caries in adults 2013 · Cochrane All outcomes
3 months (12 weeks)
SMD -1.98 [-5.42, 1.47]
2 studies · 107 participants
Very low

Interdental brushing plus toothbrushing vs Flossing plus toothbrushing

Plaque · Adults, 16 years and older (dentate)

Interdental brushing plus toothbrushing showed no clear difference in plaque (plaque indices; standardised across indices) compared with flossing plus toothbrushing (low certainty).

2 findings from 1 review · compare the 2 reviews

Interdental brushing for the prevention and control of periodontal diseases and dental caries in adults 2013 · Cochrane All outcomes
1 month (4 to 6 weeks)
SMD 0.10 [-0.13, 0.33]
7 studies · 326 participants
Low
Interdental brushing for the prevention and control of periodontal diseases and dental caries in adults 2013 · Cochrane All outcomes
3 months (12 weeks)
SMD -2.14 [-5.25, 0.97]
2 studies · 107 participants
Very low

Intervention not reported

ACR50 American College of Rheumatology 50% improvement criteria · participants with rheumatoid arthritis and with a partial response to DMARDs

The intervention probably leads to higher ACR50 American College of Rheumatology 50% improvement criteria (moderate certainty).

1 finding from 1 review

Etanercept for the treatment of rheumatoid arthritis 2013 · Cochrane Headline outcomes only
RR 1.96 [1.33, 2.89]
4 studies · 1198 participants
Moderate

Intervention not reported

Outcome: ACR50 ‐ American College of Rheumatology Improvement Criteria · participants with rheumatoid arthritis

The review found no eligible studies for this question.

1 finding from 1 review

Etanercept for the treatment of rheumatoid arthritis 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

ACR50 American College of Rheumatology improvement criteria · participants with rheumatoid arthritis and with partial response to MTX

The intervention probably leads to higher ACR50 American College of Rheumatology improvement criteria (moderate certainty).

1 finding from 1 review

Etanercept for the treatment of rheumatoid arthritis 2013 · Cochrane Headline outcomes only
RR 11.69 [1.66, 82.47]
1 study · 89 participants
Moderate

Intervention not reported

Non‐fatal macrovascular outcomes 1. Composite a. Intervention vs metformin [1a. 6 months to 4 years] b. Intervention vs thiazolidinediones [1b. 52 weeks to 4 years] c. Intervention vs meglitinide [1c. 12 months to 15 months]2. Non‐fatal myocardial... · participants with type 2 diabetes mellitus

The intervention may leads to lower non‐fatal macrovascular outcomes 1. Composite a. Intervention vs… (low certainty).

1 finding from 1 review

Sulphonylurea monotherapy for patients with type 2 diabetes mellitus 2013 · Cochrane Headline outcomes only
RR 0.67 [0.48, 0.93]
1 study · 3 participants
Low

Intervention not reported

Macrovascular outcomes · participants with type 2 diabetes mellitus

The review found no eligible studies for this question.

1 finding from 1 review

Sulphonylurea monotherapy for patients with type 2 diabetes mellitus 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found