Cochrane · systematic review · CD008409
Progesterone for acute traumatic brain injury
Ma, J, Huang, S, Qin, S, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
InjuriesAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
2
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 4 · 66.7%Very low 0 · 0%Low 1 · 16.7%Moderate 1 · 16.7%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Comparison
Population: people with acute TBI secondary to head injury
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality at end of scheduled | RR 0.91 [0.65, 1.28] | 5 studies · 2376 participants | Low Downgraded: risk of bias, inconsistency |
Disability (unfavourable outcomes: death, vegetative state, severe disability; GOS 1‐3) at end of scheduled | RR 0.98 [0.89, 1.06] | 4 studies · 2260 participants | Moderate Downgraded: risk of bias, inconsistency |
Intracranial pressure (ICP) within the treatment period | no estimate extracted | 3 studies · 3 participants | Ungraded |
Blood pressure | no estimate extracted | 1 study · 1 participants | Ungraded |
Body temperature | no estimate extracted | 1 study · 1 participants | Ungraded |
Adverse events | no estimate extracted | 4 studies · 4 participants | Ungraded |