Cochrane · systematic review · CD009454
Surgery or radiosurgery plus whole brain radiotherapy versus surgery or radiosurgery alone for brain metastases
Soon, YY, Tham, IWK, Lim, KH, et al. · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
Gynaecological, Neuro-oncology and Orphan CancerAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 6 · 100%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Comparison
Population: Patients with brain metastases
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Overall Survival (median | HR 1.11 [0.83, 1.48] | 5 studies · 663 participants | Low |
Progression free survival | HR 0.76 [0.53, 1.1] | 2 studies · 378 participants | Low |
Any intracranial disease progression at 1 year | RR 0.46 [0.35, 0.6] | 4 studies · 304 participants | Low |
Neurocognitive function | no estimate extracted | 3 studies · 209 participants | Low |
Health related quality of life | no estimate extracted | 3 studies · 436 participants | Low |
Adverse events | no estimate extracted | 4 studies · 568 participants | Low |