Cochrane · systematic review · CD004896
Antifibrinolytic drugs for acute traumatic injury
Ker, K, Roberts, I, Shakur, H, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
InjuriesAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
14
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 5 · 35.7%Moderate 5 · 35.7%High 4 · 28.6%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Antifibrinolytic drugs for bleeding trauma patients
Population: Treating bleeding trauma patients
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality | RR 0.9 [0.85, 0.96] | 3 studies · 20437 participants | High |
Surgical intervention | RR 1 [0.97, 1.03] | 3 studies · 20437 participants | High |
Blood transfusion | RR 0.98 [0.96, 1.01] | 2 studies · 20367 participants | High |
Myocardial infarction | RR 0.61 [0.4, 0.92] | 2 studies · 20367 participants | Moderate Downgraded: imprecision |
Deep vein thrombosis | RR 0.95 [0.62, 1.47] | 2 studies · 20367 participants | Moderate Downgraded: imprecision |
Stroke | RR 0.86 [0.61, 1.23] | 2 studies · 20367 participants | Moderate Downgraded: imprecision |
Pulmonary embolism | RR 1.01 [0.73, 1.41] | 2 studies · 20367 participants | Moderate Downgraded: imprecision |
Antifibrinolytic drugs for patients with traumatic brain injury
Population: Treating patients with traumatic brain injury
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality | RR 0.63 [0.4, 0.99] | 2 studies · 510 participants | Low Downgraded: indirectness |
Surgical intervention | RR 1.12 [0.65, 1.93] | 2 studies · 510 participants | Low Downgraded: indirectness |
Progressive intracranial haemorrhage | RR 0.75 [0.58, 0.98] | 2 studies · 478 participants | High |
New brain lesions | RR 0.51 [0.2, 1.32] | 1 study · 249 participants | Moderate Downgraded: imprecision, indirectness |
Myocardial infarction | RR 0.51 [0.09, 2.73] | 2 studies · 510 participants | Low Downgraded: indirectness |
Stroke | RR 0.34 [0.01, 8.35] | 2 studies · 510 participants | Low Downgraded: indirectness |
Deep vein thrombosis | RR 0.25 [0.03, 2.26] | 2 studies · 510 participants | Low Downgraded: indirectness |