Smoking cessation · people who smoke
Bupropion plus varenicline showed no clear difference in smoking cessation (at least six months of compared with varenicline alone (moderate certainty).
1 finding from 1 review
Serious adverse events · people who smoke
Bupropion plus varenicline showed no clear difference in serious adverse events compared with varenicline alone (low certainty).
1 finding from 1 review
Dropouts due to treatment · people who smoke
Bupropion plus varenicline showed no clear difference in dropouts due to treatment compared with varenicline alone (low certainty).
1 finding from 1 review
Change in weight (kg) · People who have quit smoking
Varenicline for smoking cessation showed no clear difference in mean weight change (kg) at end of treatment compared with placebo (high certainty).
3 findings from 1 review
MD 0.23
14 studies · 2566 participants
High
MD 0.09
3 studies · 384 participants
Low
MD 1.05
3 studies · 237 participants
Low
Intervention not reported
Varenicline plus behavioral intervention vs placebo plus behavioral intervention ‐ (repeated point prevalence abstinence (not even a puff/chew/session in the last 7 days) at each of weeks 5, 12, and 25 (combined), verified by CO cutoff < 10 ppm) · people who use waterpipe
The intervention showed no clear difference in varenicline plus behavioral intervention vs placebo plus behavioral… (low certainty).
1 finding from 1 review
Intervention not reported
Varenicline · adults (aged ≥ 18 years) who smoked cigarettes Components: components of pharmacological and e‐cigarette (EC) interventions for smoking…
The intervention showed no clear difference in varenicline (low certainty).
1 finding from 1 review
Intervention not reported
Varenicline · adults (aged ≥ 18 years) who smoked cigarettes Components: components of pharmacological and e‐cigarette (EC) interventions for smoking…
The intervention leads to higher varenicline (high certainty).
1 finding from 1 review
Intervention not reported
Varenicline versus placebo Smoking cessation · people who have quit smoking using a cessation intervention
The intervention probably leads to higher varenicline versus placebo Smoking cessation (moderate certainty).
1 finding from 1 review
Subgroup: varenicline only; smoking cessation (≥ 6 month · people who smoke
Reduction and pharmacotherapy probably leads to higher subgroup: varenicline only; smoking cessation (≥ 6 month compared with reduction alone (moderate certainty).
1 finding from 1 review
Intervention not reported
Cessation: Varenicline vs placebo · Smokers who cannot or do not want to quit smoking
The intervention showed no clear difference in cessation: Varenicline vs placebo (low certainty).
1 finding from 1 review
SAEs · people who smoke
Cytisine showed no clear difference in SAEs compared with varenicline (low certainty).
1 finding from 1 review
Neuropsychiatric SAEs · people who smoke
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Cardiac SAEs · people who smoke
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Smoking abstinence at longest · people who smoke
Cytisine showed no clear difference in smoking abstinence at longest compared with varenicline (low certainty).
1 finding from 1 review