Cochrane · systematic review · CD005231

Interventions to reduce harm from continued tobacco use

Lindson‐Hawley, N, Hartmann‐Boyce, J, Fanshawe, TR, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library

Tobacco AddictionAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 1 · 12.5%Very low 2 · 25%Low 5 · 62.5%Moderate 0 · 0%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

Interventions to reduce the harms caused by smoking in people who cannot or do not want to quit smoking

Population: Smokers who cannot or do not want to quit smoking
8 questions
OutcomeEffectEvidenceStatus / GRADE
Long‐term change in health status
no estimate extracted0 studies · 0 participantsUngraded
Cessation: NRT vs placebo
RR 1.87 [1.43, 2.44]8 studies · 3081 participantsLow
Downgraded: imprecision
Cessation: Bupropion vs. placebo
RR 1.27 [0.67, 2.4]1 study · 594 participantsLow
Downgraded: imprecision
Cessation: Varenicline vs placebo
RR 1.95 [0.86, 4.4]1 study · 218 participantsLow
Downgraded: imprecision
Cessation: Ecigs vs placebo
RR 2.75 [0.97, 7.76]1 study · 300 participantsLow
Downgraded: imprecision
Cessation: Snus vs placebo
RR 3.06 [0.84, 11.08]1 study · 319 participantsLow
Downgraded: imprecision
Cessation: Low‐nicotine cigarettes vs regular cigarettes
RR 1.38 [0.13, 14.79]1 study · 135 participantsVery low
Downgraded: risk of bias, imprecision
Cessation: Behavioural reduction advice vs health mailings
RR 1.49 [0.59, 3.76]1 study · 320 participantsVery low
Downgraded: imprecision, indirectness