Varenicline vs placebo: Change in weight (kg)
Varenicline for smoking cessation showed no clear difference in mean weight change (kg) at end of treatment compared with placebo (high certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Varenicline for smoking cessation vs placebo Mean weight change (kg) at end of treatment · People who have quit smoking Varenicline for smoking cessation showed no clear difference in mean weight change (kg) at end of treatment compared with placebo (high certainty). Interventions for preventing weight gain after smoking cessation (2021) · Cochrane Headline outcomes only | MD 0.23 | 14 studies · 2566 participants | High |
Varenicline for smoking cessation vs placebo Mean weight change (kg) at 6 months · People who have quit smoking Varenicline for smoking cessation showed no clear difference in mean weight change (kg) at 6 months compared with placebo (low certainty). Interventions for preventing weight gain after smoking cessation (2021) · Cochrane Headline outcomes only | MD 0.09 | 3 studies · 384 participants | Low |
Varenicline for smoking cessation vs placebo Mean weight change (kg) at 12 months · People who have quit smoking Varenicline for smoking cessation showed no clear difference in mean weight change (kg) at 12 months compared with placebo (low certainty). Interventions for preventing weight gain after smoking cessation (2021) · Cochrane Headline outcomes only | MD 1.05 | 3 studies · 237 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Interventions for preventing weight gain after smoking cessation 2021 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.