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Evidence found and GRADE certainty

4,695 questions · 4,979 findings · 433 reviews

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No studies found 998 · 20%GRADE not reported 1,140 · 22.9%Very low 1,024 · 20.6%Low 1,029 · 20.7%Moderate 636 · 12.8%High 152 · 3.1%

Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed ice held in the mouth during cancer treatment) vs no intervention or control intervention (control)

Oral mucositis (moderate to severe) · All patients with cancer who are receiving treatment

Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed… showed no clear difference in oral mucositis (moderate to severe) compared with control (no treatment or standard/usual oral care, e.g. saline rinse) (low certainty).

3 findings from 1 review

Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed ice held in the mouth during cancer treatment) vs no intervention or control intervention (control)

Number of days unable to take medicine orally · All patients with cancer who are receiving treatment

The review found no eligible studies for this question.

1 finding from 1 review

Oral vs IV followed by oral (11 days) therapy

Renal parenchymal damage at 6 to 12 months: all included children with acute pyelonephritis DMSA scans · children with acute pyelonephritis

Oral showed no clear difference in renal parenchymal damage at 6 to 12 months: all included children… compared with IV followed by oral (11 days) therapy (moderate certainty).

1 finding from 1 review

Oral vs IV followed by oral (11 days) therapy

Renal parenchymal damage at 6 to 12 months: children with renal parenchymal damage on initial DMSA · children with acute pyelonephritis

Oral showed no clear difference in renal parenchymal damage at 6 to 12 months: children with renal… compared with IV followed by oral (11 days) therapy (moderate certainty).

1 finding from 1 review

Glucosamine sulfate (oral) vs ibuprofen

Extraoral masticatory muscle tenderness (number of tender sites), change from baseline · Adults (>18 years) with temporomandibular joint osteoarthritis (TMJ OA) diagnosed by RDC/TMD or compatible criteria

Glucosamine sulfate (oral) showed no clear difference in extraoral masticatory muscle tenderness (number of tender sites),… compared with ibuprofen (oral); GRADE not reported.

1 finding from 1 review

Combined oral and intravenous vs oral or intravenous alone

Wound infection · colorectal surgery

Combined oral and intravenous leads to lower surgical wound infection: oral + iv versus iv alone compared with oral or intravenous alone (high certainty).

2 findings from 1 review

Oral vs intra‐vaginal antifungal treatment of uncomplicated vulvovaginal candidiasis

Clinical cure · women aged 16 and over with uncomplicated vulvovaginal candidiasis

Oral showed no clear difference in clinical cure (short term: 5 to 15 days) compared with intra‐vaginal antifungal treatment of uncomplicated vulvovaginal… (moderate certainty).

2 findings from 1 review

Oral vs intra‐vaginal antifungal treatment of uncomplicated vulvovaginal candidiasis

Mycological cure · women aged 16 and over with uncomplicated vulvovaginal candidiasis

Oral probably leads to higher mycological cure (short term; 5 to 15 days) compared with intra‐vaginal antifungal treatment of uncomplicated vulvovaginal… (moderate certainty).

2 findings from 1 review

Oral vs intra‐vaginal antifungal treatment of uncomplicated vulvovaginal candidiasis

Side effects (patient‐reported side effects) · women aged 16 and over with uncomplicated vulvovaginal candidiasis

Oral may leads to higher side effects (patient‐reported side effects) compared with intra‐vaginal antifungal treatment of uncomplicated vulvovaginal… (low certainty).

1 finding from 1 review