Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

45 questions · 49 findings · 14 reviews · Neonatal

No studies found 11 · 22.4%GRADE not reported 6 · 12.2%Very low 15 · 30.6%Low 8 · 16.3%Moderate 9 · 18.4%High 0 · 0%

Bubble vs ventilator or Infant Flow Driver nasal continuous positive airway pressure (CPAP)

Moderate‐severe nasal injury · preterm infants receiving nasal CPAP

Bubble probably leads to higher moderate‐severe nasal injury compared with ventilator or Infant Flow Driver nasal continuous positive airway… (moderate certainty).

1 finding from 1 review

Dextrose gel vs control

Major neurological disability at 2 years of age (Defined as any of the following: legal blindness, sensorineural deafness requiring hearing aids, moderate or severe cerebral palsy or developmental delay/intellectual impairment (developmental quoti... · newborn infants with hypoglycaemia

Oral dextrose gel showed no clear difference in major neurological disability at age 2 years or olderb Defined as… compared with control (low certainty).

1 finding from 1 review

Tracheal suction vs no tracheal suction

Moderate to severe hypoxic‐ischaemic encephalopathy (HIE) · non‐vigorous neonates born through meconium‐stained amniotic fluid

It is very uncertain whether tracheal suction changes moderate to severe hypoxic‐ischaemic encephalopathy (HIE) compared with no tracheal suction (very low certainty).

1 finding from 1 review

Intervention not reported

Chronic lung disease ‒moderate to severe BPD · infants below 33 weeks of postmenstrual age who required resuscitation in the delivery room

It is very uncertain whether the intervention changes chronic lung disease ‒moderate to severe BPD (very low certainty).

1 finding from 1 review

Use of initial sustained inflation vs standard inflations

Chronic lung disease ‐ moderate to severe BPD · preterm infants resuscitated by PPV at birth

Use of initial sustained inflation showed no clear difference in chronic lung disease ‒moderate to severe BPD compared with standard inflations (moderate certainty).

1 finding from 1 review

Very early treatment vs expectant management

Neurodevelopmental outcomes (moderate/severe cognitive delay at 18 to 24 months) · preterm infants

Very early treatment showed no clear difference in neurodevelopmental outcomes (moderate/severe cognitive delay at 18… compared with expectant management (low certainty).

1 finding from 1 review

Very early treatment vs expectant management

Neurodevelopmental outcomes (moderate/severe motor delay at 18 to 24 months) · preterm infants

Very early treatment showed no clear difference in neurodevelopmental outcomes (moderate/severe motor delay at 18 to 24… compared with expectant management (low certainty).

1 finding from 1 review

Very early treatment vs expectant management

Neurodevelopmental outcomes (moderate/severe language delay at 18 to 24 months) · preterm infants

Very early treatment showed no clear difference in neurodevelopmental outcomes (moderate/severe language delay at 18 to… compared with expectant management (low certainty).

1 finding from 1 review

Summary of Findings Table ‐ Low vs moderate‐high nasal continuous positive airway pressure levels

Death or bronchopulmonary dysplasia at 36 weeks PMA · health problem or population

It is very uncertain whether summary of Findings Table ‐ Low changes death or BPD at 36 weeks PMA compared with moderate‐high nasal continuous positive airway pressure levels (very low certainty).

1 finding from 1 review

Summary of Findings Table ‐ Low vs moderate‐high nasal continuous positive airway pressure levels

BPD at 28 days · health problem or population

The review found no eligible studies for this question.

2 findings from 1 review

Summary of Findings Table ‐ Low vs moderate‐high nasal continuous positive airway pressure levels

BPD (36 weeks' PMA) · health problem or population

It is very uncertain whether summary of Findings Table ‐ Low changes BPD, defined as supplemental oxygen or positive pressure support use… compared with moderate‐high nasal continuous positive airway pressure levels (very low certainty).

1 finding from 1 review

Summary of Findings Table ‐ Low vs moderate‐high nasal continuous positive airway pressure levels

Treatment failure or need for mechanical ventilation · health problem or population

It is very uncertain whether summary of Findings Table ‐ Low changes treatment failure or need for mechanical ventilation compared with moderate‐high nasal continuous positive airway pressure levels (very low certainty).

2 findings from 1 review

Summary of Findings Table ‐ Low vs moderate‐high nasal continuous positive airway pressure levels

Mortality before hospital discharge · health problem or population

It is very uncertain whether summary of Findings Table ‐ Low changes mortality, by hospital discharge compared with moderate‐high nasal continuous positive airway pressure levels (very low certainty).

2 findings from 1 review

Summary of Findings Table ‐ Low vs moderate‐high nasal continuous positive airway pressure levels

Bronchopulmonary dysplasia/chronic lung disease · health problem or population

It is very uncertain whether summary of Findings Table ‐ Low changes BPD, defined as supplemental oxygen or positive pressure support use… compared with moderate‐high nasal continuous positive airway pressure levels (very low certainty).

1 finding from 1 review

Summary of Findings Table ‐ Low vs moderate‐high nasal continuous positive airway pressure levels

Combined outcome of mortality or BPD at 36 weeks' PMA · health problem or population

It is very uncertain whether summary of Findings Table ‐ Low changes death or BPD at 36 weeks' PMA compared with moderate‐high nasal continuous positive airway pressure levels (very low certainty).

1 finding from 1 review