Cochrane · systematic review · CD012778
Nasal continuous positive airway pressure levels for the prevention of morbidity and mortality in preterm infants
Bamat, N, Fierro, J, Mukerji, A, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
12
current version
GRADE rated
9
No studies
3
Included studies
NR
No studies 3 · 25%Ungraded 0 · 0%Very low 9 · 75%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Summary of Findings Table ‐ Low compared to moderate‐high nasal continuous positive airway pressure levels for preterm infants receiving initial respiratory support
Population: health problem or population
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death or BPD at 36 weeks PMA Summary of Findings Table ‐ Low vs moderate‐high nasal continuous positive airway pressure levels | RR 1.02 [0.56, 1.85] | 1 study · 271 participants | Very low Downgraded: risk of bias, imprecision |
Mortality, by hospital discharge Summary of Findings Table ‐ Low vs moderate‐high nasal continuous positive airway pressure levels | RR 1.04 [0.51, 2.12] | 1 study · 271 participants | Very low Downgraded: risk of bias, imprecision |
Moderate‐severe neurodevelopmental impairment at 18 to 26 months ‐ not measured Summary of Findings Table ‐ Low vs moderate‐high nasal continuous positive airway pressure levels | no estimate extracted | NR | No studies |
BPD, defined as supplemental oxygen use at 28 days of age Summary of Findings Table ‐ Low vs moderate‐high nasal continuous positive airway pressure levels | RR 1.1 [0.56, 2.17] | 1 study · 271 participants | Very low Downgraded: risk of bias, imprecision |
BPD, defined as supplemental oxygen or positive pressure support use at 36 weeks PMA Summary of Findings Table ‐ Low vs moderate‐high nasal continuous positive airway pressure levels | RR 0.8 [0.25, 2.57] | 1 study · 271 participants | Very low Downgraded: risk of bias, imprecision |
Treatment failure or need for mechanical ventilation Summary of Findings Table ‐ Low vs moderate‐high nasal continuous positive airway pressure levels | RR 1 [0.63, 1.57] | 1 study · 271 participants | Very low Downgraded: risk of bias, imprecision |
Summary of Findings Table ‐ Low compared to moderate‐high nasal continuous positive airway pressure levels for preterm infants receiving postextubation respiratory support
Population: health problem or population
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death or BPD at 36 weeks' PMA Summary of Findings Table ‐ Low vs moderate‐high nasal continuous positive airway pressure levels | RR 0.87 [0.51, 1.49] | 1 study · 93 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Mortality, by hospital discharge Summary of Findings Table ‐ Low vs moderate‐high nasal continuous positive airway pressure levels | RR 2.94 [0.12, 70.3] | 1 study · 93 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Moderate‐severe neurodevelopmental impairment at 18 to 26 months ‐ not measured Summary of Findings Table ‐ Low vs moderate‐high nasal continuous positive airway pressure levels | no estimate extracted | NR | No studies |
BPD, defined as supplemental oxygen use at 28 days of age ‐ not measured Summary of Findings Table ‐ Low vs moderate‐high nasal continuous positive airway pressure levels | no estimate extracted | NR | No studies |
BPD, defined as supplemental oxygen or positive pressure support use at 36 weeks' PMA Summary of Findings Table ‐ Low vs moderate‐high nasal continuous positive airway pressure levels | RR 0.87 [0.51, 1.49] | 1 study · 93 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Treatment failure or need for mechanical ventilation Summary of Findings Table ‐ Low vs moderate‐high nasal continuous positive airway pressure levels | RR 1.52 [0.92, 2.5] | 2 studies · 117 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |