Unacceptability of treatment (dropouts/exclusions during the trial) · opiate‐dependent pregnant women
1 finding from 1 review
Use of substance · opiate‐dependent pregnant women
Methadone showed no clear difference in use of substance compared with oral slow‐release morphine (low certainty).
1 finding from 1 review
Completion of treatment Objective · patients with the management of opioid withdrawal
Tapered methadone showed no clear difference in completion of treatment Objective compared with any other treatment (high certainty).
1 finding from 1 review
Abstinents at · patients with the management of opioid withdrawal
Tapered methadone showed no clear difference in number of participants abstinent at compared with any other treatment (high certainty).
1 finding from 1 review
Serious adverse events or adverse events Death due to methadone use · individuals dependent on illicit opiates
1 finding from 1 review
Withdrawal symptoms · management of opium withdrawal
2 findings from 1 review
Completion of treatment · management of opium withdrawal
Pharmacological detoxification treatment may leads to higher completion of treatment: clonidine versus methadone compared with other pharmacological detoxification treatment (low certainty).
3 findings from 1 review
Completion of treatment: methadone versus methadone plus gabapentin · management of opium withdrawal
Pharmacological detoxification treatment showed no clear difference in completion of treatment: methadone versus methadone plus gabapentin compared with other pharmacological detoxification treatment (low certainty).
1 finding from 1 review
Intervention not reported
Retained in naltrexone maintenance treatment or abstinent at 12 weeks ‐ Tapered methadone comparison · patients with opioid withdrawal
The intervention showed no clear difference in retained in naltrexone maintenance treatment or abstinent at 12… (low certainty).
1 finding from 1 review
Illicit opioid use · pharmaceutical opioid dependent people
Full opioid agonists showed no clear difference in illicit opioid use compared with different full opioid agonists or partial opioid agonists (methadone… (moderate certainty).
3 findings from 1 review
no estimate extracted
1 study · 129 participants
Moderate
RR 0.81 [0.57, 1.17]
3 studies · 206 participants
Low
RR 0.49 [0.28, 0.86]
3 studies · 165 participants
Low
Retention [ · pharmaceutical opioid dependent people
Full opioid agonists may leads to higher retention compared with different full opioid agonists or partial opioid agonists (methadone… (low certainty).
1 finding from 1 review
Adverse effects · pharmaceutical opioid dependent people
Full opioid agonists showed no clear difference in adverse effects compared with different full opioid agonists or partial opioid agonists (methadone… (low certainty).
1 finding from 1 review
Neonatal or infant mortality · newborn infants with opioid withdrawal
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Neurodevelopmental disability · newborn infants with opioid withdrawal
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Length of hospital stay · newborn infants with opioid withdrawal
1 finding from 1 review
Days treatment · newborn infants with opioid withdrawal
1 finding from 1 review
Adverse events (treatment related) To discharge · newborn infants with opioid withdrawal
Morphine showed no clear difference in adverse events (treatment related) To discharge compared with methadone (low certainty).
1 finding from 1 review
Treatment failure To discharge · newborn infants with opioid withdrawal
Morphine showed no clear difference in treatment failure To discharge compared with methadone (low certainty).
1 finding from 1 review
Seizures · newborn infants with opioid withdrawal
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Abstinence · individuals dependent on illicit opiates
Dihydrocodeine showed no clear difference in abstinence compared with methadone (low certainty).
1 finding from 1 review