Full opioid agonists vs different full opioid agonists or partial opioid agonists (methadone versus buprenorphine): Illicit opioid use
Full opioid agonists showed no clear difference in illicit opioid use compared with different full opioid agonists or partial opioid agonists (methadone… (moderate certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Full opioid agonists vs different full opioid agonists or partial opioid agonists (methadone versus buprenorphine) Illicit opioid use · people dependent on pharmaceutical opioids Full opioid agonists showed no clear difference in illicit opioid use compared with different full opioid agonists or partial opioid agonists (methadone… (moderate certainty). Opioid agonist treatment for people who are dependent on pharmaceutical opioids (2022) · Cochrane Headline outcomes only | no estimate extracted | 1 study · 129 participants | Moderate |
Full opioid agonists vs different full opioid agonists or partial opioid agonists (methadone versus buprenorphine) Illicit opioid use · people dependent on pharmaceutical opioids Full opioid agonists showed no clear difference in illicit opioid use compared with different full opioid agonists or partial opioid agonists (methadone… (low certainty). Opioid agonist treatment for people who are dependent on pharmaceutical opioids (2022) · Cochrane Headline outcomes only | RR 0.81 [0.57, 1.17] | 3 studies · 206 participants | Low |
Full opioid agonists vs different full opioid agonists or partial opioid agonists (methadone versus buprenorphine) Illicit opioid use · people dependent on pharmaceutical opioids Full opioid agonists may leads to lower illicit opioid use compared with different full opioid agonists or partial opioid agonists (methadone… (low certainty). Opioid agonist treatment for people who are dependent on pharmaceutical opioids (2022) · Cochrane Headline outcomes only | RR 0.49 [0.28, 0.86] | 3 studies · 165 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Opioid agonist treatment for people who are dependent on pharmaceutical opioids 2022 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.