Morphine vs methadone: Adverse events (treatment related) To discharge
- Population
- newborn infants with opioid withdrawal
- Intervention
- Morphine
- Comparison
- methadone
- Outcome
- Adverse events (treatment related) To discharge
Morphine showed no clear difference in adverse events (treatment related) To discharge compared with methadone (low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Morphine vs methadone Adverse events (treatment related) To discharge · newborn infants with opioid withdrawal Morphine showed no clear difference in adverse events (treatment related) To discharge compared with methadone (low certainty). Opioid treatment for opioid withdrawal in newborn infants (2021) · Cochrane Headline outcomes only | RR 0.33 [0.01, 8.02] | 1 study · 116 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- Morphine vs buprenorphine · newborn infants with opioid withdrawal · 1 review
- Morphine vs dilute tincture of opium · newborn infants with opioid withdrawal · 1 review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.