Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

267 questions · 280 findings · 47 reviews

No studies found 80 · 28.6%GRADE not reported 11 · 3.9%Very low 96 · 34.3%Low 50 · 17.9%Moderate 40 · 14.3%High 3 · 1.1%

Postbiotic toothpaste vs Fluoride toothpaste alone

Increased salivary pH · children aged 6‐12 years

Postbiotic toothpaste raises salivary pH in one pediatric RCT (ungraded).

1 finding from 1 review
  • Postbiotics and Dental Caries: A Systematic Review. 2025 All outcomes
    4 weeks · Clinical; salivary/plaque sampling
    Postbiotic toothpaste significantly increased salivary pH versus fluoride toothpaste in children (Basir 2022); postbiotics are also proposed to buffer acidic pH; no pooled estimate.
    1 study
    GRADE not reported

Intervention not reported

Number of participants with an increased creatinine level · people with TSC

The intervention probably leads to lower number of participants with an increased creatinine level (moderate certainty).

1 finding from 1 review

Intervention not reported

Finding 6. Patients, caregivers, and providers described a number of privacy and confidentiality issues when services were provided at home. These included the increased privacy of being able to exercise at home but also the loss of privacy when e...

The review found no eligible studies for this question.

1 finding from 1 review

Yoga vs no exercise

Adverse events (1 participant withdrew due to increased back pain) · patients with non‐specific chronic low back pain

Yoga may leads to higher adverse events (1 participant withdrew due to increased back pain) compared with non‐exercise (low certainty).

1 finding from 1 review

Photobiomodulation treatment vs no treatment/sham

Adverse events: AMD progression at 12 months Defined as increased drusen volume or onset of advanced AMD. Conversion to exudative AMD at 12 months Assessed by clinical examination and retinal optical coherence tomography. · people with non‐exudative AMD (AREDS 2 to 4)

Photobiomodulation treatment showed no clear difference in adverse events: AMD progression at 12 months Defined as increased… compared with sham or no treatment (low certainty).

1 finding from 1 review

Transepithelial CXL using iontophoresis vs epithelium‐off CXL

Proportion of participants whose maximum K increased by at least 2 diopters—at 24 months · participants with progressive keratoconus

It is very uncertain whether transepithelial CXL using iontophoresis changes proportion of participants whose maximum K increased by at least 2… compared with epithelium‐off CXL (very low certainty).

1 finding from 1 review

Transepithelial CXL vs epithelium‐off CXL

Proportion of participants whose maximum K increased by at least 2 diopters—at 12 months · participants with keratoconus

It is very uncertain whether transepithelial CXL changes proportion of participants whose maximum K increased by at least 2… compared with epithelium‐off CXL (very low certainty).

1 finding from 1 review

Therapeutic ultrasound vs placebo

Pain intensity VAS (0 to 100; 0 = no pain, 100 = worst pain) · adults with chronic low‐back pain

It is very uncertain whether therapeutic ultrasound changes pain intensity Scale: VAS (100‐point scale; higher scores mean… compared with placebo (very low certainty).

1 finding from 1 review

Therapeutic ultrasound plus exercise vs exercise

Pain intensity VAS (0 to 100; 0 = no pain, 100 = worst pain) · adults with chronic low‐back pain

It is very uncertain whether therapeutic ultrasound plus exercise changes pain intensity Scale: VAS (100‐point scale; higher scores mean… compared with exercise alone (very low certainty).

1 finding from 1 review

Ovarian stimulating drugs in subfertile women vs subfertile women not treated or versus general population

Risk of invasive ovarian cancer in subfertile women exposed to ovarian stimulating drug vs unexposed women (summary of cohort studies suggesting increased risk) · subfertile women
2 findings from 1 review

Ovarian stimulating drugs in subfertile women vs subfertile women not treated or versus general population

Risk of borderline ovarian cancer in subfertile women exposed to ovarian stimulating drugs vs unexposed women (summary of case‐control studies suggesting an increase) · subfertile women
1 finding from 1 review

IM injection vs IA injection

Improvement in lower limb perfusion: ABI · people with critical limb ischaemia

It is very uncertain whether IM injection changes improvement in lower limb perfusion: number of participants with… compared with IA injection (very low certainty).

1 finding from 1 review