Cochrane · systematic review · CD013283
First aid glucose administration routes for symptomatic hypoglycaemia
De Buck, E, Borra, V, Carlson, JN, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
Metabolic and Endocrine DisordersAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
20
current version
GRADE rated
8
No studies
12
Included studies
NR
No studies 12 · 60%Ungraded 0 · 0%Very low 8 · 40%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Sublingual glucose compared to oral (swallowed) glucose for treatment of hypoglycaemia
Population: children with hypoglycaemia associated with moderate clinical symptoms of acute malaria or moderate respiratory tract infections
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Resolution of symptoms, time to resolution of symptoms Sublingual glucose vs oral (swallowed) glucose | no estimate extracted | NR | No studies |
Blood/plasma glucose concentrations at 20 minutes Sublingual glucose vs oral (swallowed) glucose | no estimate extracted | 1 study · 42 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Resolution of hypoglycaemia Definition: (a) within 20 minutes (b) within 80 minutes Sublingual glucose vs oral (swallowed) glucose | RR 1.26 [0.91, 1.74] | 1 study · 42 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Time to resolution of hypoglycaemia Sublingual glucose vs oral (swallowed) glucose | no estimate extracted | 1 study · 42 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Adverse events Sublingual glucose vs oral (swallowed) glucose | no estimate extracted | 1 study · 42 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Treatment delay Sublingual glucose vs oral (swallowed) glucose | no estimate extracted | NR | No studies |
Buccal glucose compared to oral (swallowed) glucose for treatment of hypoglycaemia
Population: healthy volunteers (adults)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Resolution of symptoms, time to resolution of symptoms Buccal glucose vs oral (swallowed) glucose | no estimate extracted | NR | No studies |
Blood/plasma glucose concentrations at 20 minutes Buccal glucose vs oral (swallowed) glucose | no estimate extracted | 1 study · 16 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Increased blood glucose at 20 minutes Buccal glucose vs oral (swallowed) glucose | RR 0.07 [0, 0.98] | 1 study · 7 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Resolution of hypoglycaemia Buccal glucose vs oral (swallowed) glucose | no estimate extracted | NR | No studies |
Time to resolution of hypoglycaemia Buccal glucose vs oral (swallowed) glucose | no estimate extracted | NR | No studies |
Adverse events Buccal glucose vs oral (swallowed) glucose | no estimate extracted | NR | No studies |
Ease of administration/treatment delay Buccal glucose vs oral (swallowed) glucose | no estimate extracted | NR | No studies |
Oral + buccal glucose (dextrose gel) compared to oral (swallowed) glucose for treatment of hypoglycaemia
Population: adult patients with insulin‐dependent diabetes
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Resolution of symptoms within 20 minutes Oral + buccal glucose (dextrose gel) vs oral (swallowed) glucose | RR 0.36 [0.12, 1.14] | 1 study · 18 participants | Very low Downgraded: risk of bias, imprecision |
Time to resolution of symptoms Oral + buccal glucose (dextrose gel) vs oral (swallowed) glucose | no estimate extracted | NR | No studies |
Blood/plasma glucose concentrations at 20 minutes Oral + buccal glucose (dextrose gel) vs oral (swallowed) glucose | no estimate extracted | 1 study · 18 participants | Very low Downgraded: imprecision |
Resolution of hypoglycaemia Oral + buccal glucose (dextrose gel) vs oral (swallowed) glucose | no estimate extracted | NR | No studies |
Time to resolution of hypoglycaemia Oral + buccal glucose (dextrose gel) vs oral (swallowed) glucose | no estimate extracted | NR | No studies |
Adverse events Oral + buccal glucose (dextrose gel) vs oral (swallowed) glucose | no estimate extracted | NR | No studies |
Ease of administration/treatment delay Oral + buccal glucose (dextrose gel) vs oral (swallowed) glucose | no estimate extracted | NR | No studies |