Cochrane · systematic review · CD008215
Risk of ovarian cancer in women treated with ovarian stimulating drugs for infertility
Rizzuto, I, Behrens, RF, Smith, LA · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
Gynaecological, Neuro-oncology and Orphan CancerAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
4
current version
GRADE rated
4
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 4 · 100%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Ovarian stimulating drugs in subfertile women compared to subfertile women not treated or versus general population for subfertile women
Population: for subfertile women
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Risk of invasive ovarian cancer in subfertile women exposed to ovarian stimulating drug vs unexposed women (summary of cohort studies suggesting increased risk) Ovarian stimulating drugs in subfertile women vs subfertile women not treated or versus general population | no estimate extracted | 4 studies · 194583 participants | Very low |
Risk of invasive ovarian cancer in subfertile women exposed to ovarian stimulating drugs vs unexposed women (summary of case‐control studies suggesting increased risk) Ovarian stimulating drugs in subfertile women vs subfertile women not treated or versus general population | no estimate extracted | 2 studies · 35 participants | Very low Downgraded: risk of bias |
Risk of borderline ovarian tumours in subfertile women exposed to ovarian stimulating drugs vs unexposed women (summary of cohort studies suggesting increased risk) Ovarian stimulating drugs in subfertile women vs subfertile women not treated or versus general population | no estimate extracted | 5 studies · 1381732 participants | Very low Downgraded: risk of bias |
Risk of borderline ovarian cancer in subfertile women exposed to ovarian stimulating drugs vs unexposed women (summary of case‐control studies suggesting an increase) Ovarian stimulating drugs in subfertile women vs subfertile women not treated or versus general population | no estimate extracted | 2 studies · 28 participants | Very low Downgraded: risk of bias |