Findings

What do systematic reviews say?

1,773 questions · 1,817 findings · 212 reviews · Headline outcomes only

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No studies found 383 · 21.1%GRADE not reported 192 · 10.6%Very low 472 · 26%Low 444 · 24.4%Moderate 228 · 12.5%High 98 · 5.4%

HES vs placebo or no treatment

Adverse effects · women at high risk of OHSS

The review found no eligible studies for this question.

1 finding from 1 review

Volume expanders for the prevention of ovarian hyperstimulation syndrome 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

High MW HES vs Low MW HES

RIFLE (Risk or worse) · patients with Intravascular Volume Depletion

High MW HES showed no clear difference in RIFLE (Risk or worse) compared with low MW HES (moderate certainty).

1 finding from 1 review

Hydroxyethyl starch (HES) versus other fluid therapies: effects on kidney function 2010 · Cochrane Headline outcomes only
RR 0.54 [0.05, 5.59]
2 studies · 113 participants
Moderate

High MW HES vs Low MW HES

RIFLE (Injury or worse) · patients with Intravascular Volume Depletion

High MW HES showed no clear difference in RIFLE (Injury or worse) compared with low MW HES (moderate certainty).

1 finding from 1 review

Hydroxyethyl starch (HES) versus other fluid therapies: effects on kidney function 2010 · Cochrane Headline outcomes only
RR 3.21 [0.14, 75.68]
3 studies · 162 participants
Moderate

High MW HES vs Low MW HES

RIFLE (Failure) · patients with Intravascular Volume Depletion

1 finding from 1 review

Hydroxyethyl starch (HES) versus other fluid therapies: effects on kidney function 2010 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 162 participants
Moderate

Tissue adhesive vs tape

Wound dehiscence · people with surgical incisions

Tissue adhesive showed no clear difference in wound dehiscence compared with adhesive tape (low certainty).

1 finding from 1 review

Tissue adhesives for closure of surgical incisions 2014 · Cochrane Headline outcomes only
RR 0.96 [0.06, 14.55]
1 study · 50 participants
Low

Tissue adhesive vs tape

Wound infection · people with surgical incisions

Tissue adhesive showed no clear difference in wound infection compared with adhesive tape (low certainty).

1 finding from 1 review

Tissue adhesives for closure of surgical incisions 2014 · Cochrane Headline outcomes only
RR 1.37 [0.39, 4.81]
3 studies · 190 participants
Low

Local anaesthesia vs general anaesthesia

Any stroke within 30 days of operation (primary outcome) · patients with symptomatic or asymptomatic carotid disease

1 finding from 1 review

Local versus general anaesthesia for carotid endarterectomy 2021 · Cochrane Headline outcomes only
0.91 [0.66, 1.26]
13 studies · 4663 participants
Moderate

Local anaesthesia vs general anaesthesia

Death within 30 days of operation · patients with symptomatic or asymptomatic carotid disease

Local anaesthesia showed no clear difference in death within 30 days of operation compared with general anaesthesia (low certainty).

1 finding from 1 review

Local versus general anaesthesia for carotid endarterectomy 2021 · Cochrane Headline outcomes only
OR 0.61 [0.35, 1.06]
12 studies · 4421 participants
Low

Local anaesthesia vs general anaesthesia

Perioperative ipsilateral stroke (< 30 days) · patients with symptomatic or asymptomatic carotid disease

Local anaesthesia showed no clear difference in ipsilateral stroke within 30 days of operation compared with general anaesthesia (low certainty).

1 finding from 1 review

Local versus general anaesthesia for carotid endarterectomy 2021 · Cochrane Headline outcomes only
OR 1.03 [0.71, 1.48]
2 studies · 3733 participants
Low

Local anaesthesia vs general anaesthesia

Perioperative death and strokes · patients with symptomatic or asymptomatic carotid disease

Local anaesthesia showed no clear difference in stroke or death within 30 days of operation compared with general anaesthesia (moderate certainty).

1 finding from 1 review

Local versus general anaesthesia for carotid endarterectomy 2021 · Cochrane Headline outcomes only
OR 0.85 [0.62, 1.16]
11 studies · 4391 participants
Moderate

Local anaesthesia vs general anaesthesia

Myocardial infarction (0 to 30 days) · patients with symptomatic or asymptomatic carotid disease

Local anaesthesia showed no clear difference in myocardial infarction within 30 days of operation compared with general anaesthesia (low certainty).

1 finding from 1 review

Local versus general anaesthesia for carotid endarterectomy 2021 · Cochrane Headline outcomes only
OR 1.53 [0.67, 3.47]
12 studies · 4567 participants
Low

Local anaesthesia vs general anaesthesia

Local haemorrhage · patients with symptomatic or asymptomatic carotid disease

Local anaesthesia showed no clear difference in local haemorrhage compared with general anaesthesia (moderate certainty).

1 finding from 1 review

Local versus general anaesthesia for carotid endarterectomy 2021 · Cochrane Headline outcomes only
OR 0.99 [0.79, 1.25]
6 studies · 4186 participants
Moderate

Local anaesthesia vs general anaesthesia

Arteries shunted · patients with symptomatic or asymptomatic carotid disease

Local anaesthesia may leads to lower arteries shunted compared with general anaesthesia (low certainty).

1 finding from 1 review

Local versus general anaesthesia for carotid endarterectomy 2021 · Cochrane Headline outcomes only
OR 0.25 [0.22, 0.29]
8 studies · 4133 participants
Low

Lung cancer screening with chest radiography +/‐ sputum cytology vs less intense screening

Mortality: lung cancer · Patients with lung cancer

Lung cancer screening with chest radiography +/‐ sputum cytology showed no clear difference in lung cancer mortality ‐ More frequent chest x‐ray screening versus… compared with less intense screening (moderate certainty).

2 findings from 1 review

Screening for lung cancer 2013 · Cochrane Headline outcomes only
RR 1.11 [0.95, 1.31]
4 studies · 81303 participants
Moderate
Screening for lung cancer 2013 · Cochrane Headline outcomes only
RR 0.88 [0.74, 1.03]
2 studies · 20427 participants
High

Lung cancer screening with chest radiography +/‐ sputum cytology vs less intense screening

All‐cause mortality ‐ More frequent chest x‐ray screening versus less frequent screening · Patients with lung cancer

Lung cancer screening with chest radiography +/‐ sputum cytology showed no clear difference in all‐cause mortality ‐ More frequent chest x‐ray screening versus… compared with less intense screening (low certainty).

1 finding from 1 review

Screening for lung cancer 2013 · Cochrane Headline outcomes only
RR 1.01 [0.94, 1.08]
4 studies · 170149 participants
Low

Lung cancer screening with chest radiography +/‐ sputum cytology vs less intense screening

All‐cause mortality ‐ Annual chest x‐ray plus 4‐monthly cytology versus annual x‐ray alone · Patients with lung cancer

Lung cancer screening with chest radiography +/‐ sputum cytology showed no clear difference in all‐cause mortality ‐ Annual chest x‐ray plus 4‐monthly cytology… compared with less intense screening (high certainty).

1 finding from 1 review

Screening for lung cancer 2013 · Cochrane Headline outcomes only
RR 1.03 [0.91, 1.15]
1 study · 10040 participants
High

Lung cancer screening with chest radiography +/‐ sputum cytology vs less intense screening

Lung cancer 5‐year survival ‐ More frequent chest x‐ray screening versus less frequent screening · Patients with lung cancer

Lung cancer screening with chest radiography +/‐ sputum cytology may leads to lower lung cancer 5‐year survival ‐ More frequent chest x‐ray screening… compared with less intense screening (low certainty).

1 finding from 1 review

Screening for lung cancer 2013 · Cochrane Headline outcomes only
RR 0.91 [0.84, 0.99]
4 studies · 1775 participants
Low

Lung cancer screening with chest radiography +/‐ sputum cytology vs less intense screening

Lung cancer 5‐year survival ‐ Annual chest x‐ray plus 4‐monthly cytology versus annual x‐ray alone · Patients with lung cancer

Lung cancer screening with chest radiography +/‐ sputum cytology probably leads to lower lung cancer 5‐year survival ‐ Annual chest x‐ray plus 4‐monthly… compared with less intense screening (moderate certainty).

1 finding from 1 review

Screening for lung cancer 2013 · Cochrane Headline outcomes only
RR 0.83 [0.75, 0.92]
1 study · 837 participants
Moderate

General anaesthesia vs non‐general anaesthesia

Functional outcomes · acute ischaemic stroke endovascular treatment (long‐term)

3 findings from 1 review

Type of anaesthesia for acute ischaemic stroke endovascular treatment 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 90 participants
Very low
Type of anaesthesia for acute ischaemic stroke endovascular treatment 2022 · Cochrane Headline outcomes only
RR 1.21 [0.93, 1.58]
4 studies · 625 participants
Low
Type of anaesthesia for acute ischaemic stroke endovascular treatment 2022 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 978 participants
Low

General anaesthesia vs non‐general anaesthesia

Neurological impairment · acute ischaemic stroke endovascular treatment (long‐term)

The review found no eligible studies for this question.

2 findings from 1 review

Type of anaesthesia for acute ischaemic stroke endovascular treatment 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found
Type of anaesthesia for acute ischaemic stroke endovascular treatment 2022 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 982 participants
Low