Oral health-related quality of life · Indian adults and elderly (general, police, teachers, institutionalised)
No difference in OHRQoL was seen between groups for periodontal disease by LOA on OHIP-14/OIDP (pooled SMD -0.04, CI includes 0); ungraded.
2 findings from 1 review
SMD -0.04 [-2.01, 1.92]
4 studies · 3414 participants
Very low
Periodontal disease (LOA) and QoL (continuous, GOHAI): one study reported a significant negative impact (Rekhi 2016), one found no significant association (Marya 2020). Not pooled.
2 studies
GRADE not reported
Oral health-related quality of life · Indians
Continuous analyses (GOHAI, OHIP-14) of gingivitis and OHRQoL were inconsistent and mostly non-significant; ungraded.
1 finding from 1 review
Gingivitis and QoL (continuous): GOHAI - one study found poorer QoL (Appukuttan 2016, P<0.05), one no significant association (Marya 2020, P=0.08); OHIP-14 - no impact (Sreela 2020, P=0.0762). Not pooled.
3 studies
GRADE not reported
Oral health-related quality of life · Indian adults and elderly (general, police, teachers, institutionalised)
No difference in OHRQoL was seen between groups for periodontal disease by CPI on OHIP-14/OIDP (pooled SMD -0.18, CI includes 0); ungraded.
2 findings from 1 review
SMD -0.18 [-0.53, 0.18]
4 studies · 3064 participants
Very low
Periodontal disease (CPI) and QoL (continuous, GOHAI): CPI scores negatively correlated with QoL in one study (Rekhi 2016); no significant relation in another (Marya 2020, P>0.05). Not pooled.
2 studies
GRADE not reported
Oral health-related quality of life · Indians
Three studies using GOHAI found dental caries associated with poorer OHRQoL (P<0.05); narrative, ungraded.
2 findings from 1 review
Dental caries and QoL (GOHAI): all three studies (Appukuttan 2016, Rekhi 2018, Rekhi 2015) found decayed teeth associated with poorer QoL (P<0.05); not pooled.
3 studies
GRADE not reported
SMD 0.87 [0.34, 1.40]
6 studies · 4511 participants
Moderate
Oral health-related quality of life · Indian elderly
Continuous (GOHAI/WHOQoL) evidence on edentulism and OHRQoL was inconsistent across two studies; ungraded.
2 findings from 1 review
Edentulism and QoL (continuous, GOHAI/WHOQoL): one study reported edentulism negatively influenced QoL (Marina 2019), one found no effect (Appukuttan 2016). Not pooled.
2 studies
GRADE not reported
Edentulism and QoL (continuous, OHIP-14): no significant association between individuals with and without edentulism (Ajai 2020). Single study, not pooled.
1 study
GRADE not reported
Oral health-related quality of life · Indian children aged 3-5 years
In children aged 3-5 years, early childhood caries was significantly associated with poorer OHRQoL (narrative; 3 studies); ungraded.
1 finding from 1 review
Oral health-related quality of life · Indian children and young adults
Two studies found dental fluorosis significantly associated with poorer OHRQoL; narrative, ungraded.
1 finding from 1 review
Dental fluorosis and QoL (continuous, OIDP/CPQ11-14): a significant difference between individuals with and without fluorosis on OHRQoL (Nagarajappa 2015, Shyam 2020). Two studies, 3000 individuals; not pooled.
2 studies · 3000 participants
GRADE not reported
Oral health-related quality of life · Indian elderly
No significant difference in OHRQoL (GOHAI) was found for functional edentulism vs none (pooled SMD 0.31, CI includes 0); ungraded.
1 finding from 1 review
Oral health-related quality of life · Indian elderly and general-population adults
One study found prosthetic need significantly related to OHRQoL components on OHIP-14; ungraded.
2 findings from 1 review
Prosthetic need and QoL (continuous, OHIP-14): prosthetic need was significantly related to various components of OHRQoL (Joseph 2016). Single study, not pooled.
1 study
GRADE not reported
Prosthetic need and QoL (continuous, GOHAI): of three studies, one found no significant difference (Shetty 2013) and two proved the association (Pillai 2015, Rekhi 2018). Not pooled.
3 studies
GRADE not reported
Postoperative pain intensity in the immediate postobturation period (up to 72 hours), continuous (VAS) · People aged 10 years or above requiring root canal treatment; permanent teeth with completely formed apex and without internal resorption
Single-visit root canal treatment showed no clear difference in postoperative pain intensity in the immediate postobturation period… compared with multiple-visit root canal treatment (two or more visits) (low certainty).
1 finding from 1 review
Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · People undergoing tooth extraction (21 of 23 trials: healthy patients undergoing impacted third molar extraction; 1 routine intra-alveolar…
It is very uncertain whether systemic antibiotic prophylaxis (any regimen; topical therapy… changes pain (continuous, VAS 0-10 cm, 7th day) compared with placebo (very low certainty).
1 finding from 1 review
Taste acuity improvement - objective outcome (continuous) - individual taste sensations · Patients with taste disturbances (dysgeusia/hypogeusia; idiopathic, zinc-deficient, or secondary to chronic renal failure)
Zinc supplements (zinc sulphate, zinc gluconate, zinc picolinate,… showed no clear difference in taste acuity improvement - objective outcome (continuous) -… compared with placebo; GRADE not reported.
1 finding from 1 review
Interventions for managing taste disturbances 2017 · Cochrane All outcomesChronic renal failure
Results (Mahajan 1980, chronic renal failure; Analysis 1.3): mean difference by taste sensation - salt MD 285 (95% CI 238.75 to 331.25); sweet MD 190 (142.36 to 237.64); sour MD 10 (-16.43 to 36.43); bitter MD 2.40…
1 study · 22 participants
GRADE not reported
Taste acuity improvement - objective outcome (continuous) - taste detection (cross-over trial) · Patients with taste disturbances (dysgeusia/hypogeusia; idiopathic, zinc-deficient, or secondary to chronic renal failure)
It is very uncertain whether zinc supplements (zinc sulphate, zinc gluconate, zinc picolinate,… changes taste acuity improvement - objective outcome (continuous) - taste… compared with placebo (very low certainty).
1 finding from 1 review
Taste acuity improvement - objective outcome (continuous) - taste recognition (cross-over trial) · Patients with taste disturbances (dysgeusia/hypogeusia; idiopathic, zinc-deficient, or secondary to chronic renal failure)
It is very uncertain whether zinc supplements (zinc sulphate, zinc gluconate, zinc picolinate,… changes taste acuity improvement - objective outcome (continuous) - taste… compared with placebo (very low certainty).
1 finding from 1 review
Taste acuity improvement - objective outcome (continuous data) · Patients with taste disturbances (dysgeusia/hypogeusia; idiopathic, zinc-deficient, or secondary to chronic renal failure)
It is very uncertain whether zinc supplements (zinc sulphate, zinc gluconate, zinc picolinate,… changes taste acuity improvement - objective outcome (continuous data) compared with placebo (very low certainty).
1 finding from 1 review
Dry mouth (xerostomia) · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region
It is very uncertain whether pilocarpine changes xerostomia (continuous, combined SMD) compared with no treatment/placebo (very low certainty).
1 finding from 1 review
Postoperative pain (continuous measure: self report using visual analogue scale) · Children and adolescents having orthodontic separator placement (without local anaesthetic)
Preoperative ibuprofen may leads to lower postoperative pain (continuous measure: self report using visual… compared with placebo (low certainty).
1 finding from 1 review
Tactile sensitivity (method b, continuous probe) · Healthy human adults (18 years or more) with dentine hypersensitivity from exposed root surfaces
Potassium containing toothpaste (5% potassium nitrate) led to higher tactile sensitivity (method b, continuous probe) compared with control toothpaste (without potassium); GRADE not reported.
1 finding from 1 review
All-cause mortality (ACM) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies
Each additional lost tooth was associated with a multivariable-adjusted HR of 1.02 (95% CI 1.01 to 1.03) for all-cause mortality (11 studies, I2=89%), statistically significant; GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources).
3 findings from 1 review
Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies
Each additional lost tooth was associated with a multivariable-adjusted HR of 1.02 (95% CI 1.01 to 1.03) for ACVD-related events (13 studies, I2=75%), statistically significant; GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources).
3 findings from 1 review