Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

677 questions · 719 findings · 133 reviews

No studies found 153 · 21.3%GRADE not reported 54 · 7.5%Very low 164 · 22.8%Low 199 · 27.7%Moderate 119 · 16.6%High 30 · 4.2%

Pre‐mixed insulin (70 NPH/30 REG) vs self‐mixed split dose insulin (Different insulin regimens with similar insulin types used within the regimen)

Macrosomia · pregnant women with pre‐existing diabetes

It is very uncertain whether pre‐mixed insulin (70 NPH/30 REG) changes macrosomia compared with self‐mixed split dose insulin (Different insulin regimens with… (very low certainty).

1 finding from 1 review

Insulin injected with a Novolin pen vs insulin injected with a needle or syringe (Different insulin regimens with similar insulin types used within the regimen)

Macrosomia · pregnant women with pre‐existing diabetes

It is very uncertain whether insulin injected with a Novolin pen changes macrosomia compared with insulin injected with a needle or syringe (Different insulin… (very low certainty).

1 finding from 1 review

Human insulin vs animal insulin (Different insulin types within similar insulin regimens)

Macrosomia · pregnant women with pre‐existing diabetes

It is very uncertain whether human insulin changes macrosomia compared with animal insulin (Different insulin types within similar insulin… (very low certainty).

1 finding from 1 review

Celecoxib vs placebo

Clinical improvement: American College of Rheumatology 20% improvement criteria (ACR20) · patients with rheumatoid arthritis

Celecoxib probably leads to higher clinical improvement: American College of Rheumatology 20%… compared with placebo (moderate certainty).

1 finding from 1 review

Celecoxib vs NSAIDs

Clinical improvement: American College of Rheumatology 20% improvement criteria (ACR20) · patients with rheumatoid arthritis

Celecoxib showed no clear difference in clinical improvement: American College of Rheumatology 20%… compared with traditional NSAIDs (moderate certainty).

1 finding from 1 review

Intervention not reported

Pain Acroparaesthesia and Fabry crises · Anderson‐Fabry disease

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Cocaine use assessed by the mean (SD) proportion of cocaine‐free urinalysis across the study per participant · people with cocaine dependence
1 finding from 1 review

Intervention not reported

Intracranial pressure (ICP) within the treatment period · people with acute TBI secondary to head injury
1 finding from 1 review

Initiation of water fluoridation (artificial or natural) vs Low/non-fluoridated water (0.4 ppm fluoride or less)

Disparities in caries across socioeconomic status (SES) · People of all ages in a community setting; the included caries studies were all in children aged 3 to 16 years
1 finding from 1 review
  • There is insufficient information to determine whether initiation of a water fluoridation programme results in a change in disparities in caries levels across SES. Data from 3 observational studies (participants not…
    3 studies · 35399 participants
    Low

Intervention not reported

Progressive intracranial haemorrhage · Treating patients with traumatic brain injury

The intervention leads to lower progressive intracranial haemorrhage (high certainty).

1 finding from 1 review

Liberal vs restrictive transfusion protocols

Inability to walk 10 feet (3 m; or across a room) without human assistance · Patients with hip fracture repair

Liberal showed no clear difference in inability to walk 10 feet (3 m; or across a room) without human… compared with restrictive threshold transfusion (low certainty).

1 finding from 1 review

Cessation of water fluoridation (fluoride removed from the water supply) vs Continued fluoridated water

Disparities in caries across socioeconomic status (SES) · People of all ages in a previously fluoridated community (Maupome 2001: children with generally low caries experience)

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

ACR 50 American College of Rheumatology improvement criteria · patients with rheumatoid arthritis

The intervention probably leads to higher ACR 50 American College of Rheumatology improvement criteria (moderate certainty).

1 finding from 1 review