Cochrane · systematic review · CD011639
Maintenance immunosuppression for adults undergoing liver transplantation: a network meta‐analysis
Rodríguez‐Perálvarez, M, Guerrero‐Misas, M, Thorburn, D, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
Hepato-BiliaryAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
12
current version
GRADE rated
11
No studies
1
Included studies
NR
No studies 1 · 8.3%Ungraded 0 · 0%Very low 10 · 83.3%Low 1 · 8.3%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Maintenance immunosuppressive regimens for adults undergoing liver transplantation: a network meta‐analysis
Population: people undergoing liver transplantation
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Interventions | no estimate extracted | NR | No studies |
Cyclosporine A | HR 1.1 [0.56, 2.34] | 8 studies · 1176 participants | Very low Downgraded: indirectness |
Cyclosporine A plus azathioprine | HR 1.31 [0.05, 31.94] | 2 studies · 202 participants | Very low Downgraded: indirectness |
Cyclosporine A plus azathioprine plus glucocorticosteroids | no estimate extracted | NR | Very low Downgraded: indirectness |
Cyclosporine A plus glucocorticosteroids | no estimate extracted | NR | Very low Downgraded: indirectness |
Cyclosporine A plus mycophenolate plus glucocorticosteroids | no estimate extracted | NR | Very low Downgraded: indirectness |
Everolimus | HR 1.62 [0.73, 3.99] | 1 study · 474 participants | Very low Downgraded: indirectness |
Tacrolimus plus azathioprine | HR 0.46 [0.17, 1.15] | 1 study · 97 participants | Very low Downgraded: indirectness |
Tacrolimus plus everolimus | HR 1.43 [0.63, 3.38] | 1 study · 488 participants | Very low Downgraded: indirectness |
Tacrolimus plus glucocorticosteroids | no estimate extracted | NR | Very low Downgraded: indirectness |
Tacrolimus plus mycophenolate plus glucocorticosteroids | HR 0.58 [0.14, 1.91] | 1 study · 195 participants | Very low Downgraded: indirectness |
Tacrolimus plus sirolimus | HR 2.76 [1.3, 6.69] | 1 study · 222 participants | Low Downgraded: indirectness |