Search review questions

Low risk of bias adult studies, mortality all‐cause ‐ IgM‐enriched IVIG · adult patients with sepsis, severe sepsis and septic shock

Anti‐endotoxins versus placebo, all‐cause mortality · patients with sepsis, severe sepsis, septic shock

ICU length of stay (general intensive care patients) · Adult patients in intensive care

Hospital length of stay (general intensive care patients) · Adult patients in intensive care

Hospital length of stay (high‐risk surgical patients) · Adult patients in intensive care

Cost of care (hospital charges, 1000s of US dollars) · Adult patients in intensive care

Combined mortality of all studies · Adult patients in intensive care

Catheter‐related BSI as defined using criteria specified by Maki 2006; Mermel 2009; and O'Grady 2002 · patients with intravenous administration set replacement

Infusate‐related BSI as defined using criteria specified by O'Grady 2002 · patients with intravenous administration set replacement

Infusate colonization any positive quantitative culture of infusate · patients with intravenous administration set replacement

Catheter colonization any positive semiquantitative or quantitative culture from the distal catheter segment · patients with intravenous administration set replacement

All‐cause BSI any positive blood culture drawn from a peripheral vein taken whilst the IVD is in situ, or within 48 hours of removal (O'Grady 2002) · patients with intravenous administration set replacement

Mortality · patients with intravenous administration set replacement

d mortality · mechanically ventilated participants with acute lung injury and acute respiratory distress syndrome

Number of days free of mechanical ventilation in a 28 d period · mechanically ventilated participants with acute lung injury and acute respiratory distress syndrome

Adverse events · mechanically ventilated participants with acute lung injury and acute respiratory distress syndrome

Hypoxia · mechanically ventilated participants with acute lung injury and acute respiratory distress syndrome

Pneumothorax · mechanically ventilated participants with acute lung injury and acute respiratory distress syndrome

Hypotension · mechanically ventilated participants with acute lung injury and acute respiratory distress syndrome

Bradycardia · mechanically ventilated participants with acute lung injury and acute respiratory distress syndrome

Cardiac arrest · mechanically ventilated participants with acute lung injury and acute respiratory distress syndrome

Mortality—COPD · intubated adults with respiratory failure

Mortality—mixed · intubated adults with respiratory failure

Weaning failure · patients with intubated adults with respiratory failure

Nosocomial pneumonia · patients with intubated adults with respiratory failure

Average duration of ventilation related to weaning · patients with intubated adults with respiratory failure

Reintubation · patients with intubated adults with respiratory failure

Reduction in airway resistance Measured as a reduction in additional effective resistance (ΔRrs) and interrupter resistance (Rint) Assessed before treatment and 30 minutes after the end of each modality of administration · mechanically ventilated adults with need for aerosol bronchodilator therapy

Mortality during critical care unit admission Measured using mortality rate in intervention and comparison groups During critical care admission · mechanically ventilated adults with need for aerosol bronchodilator therapy

Duration of mechanical ventilation Measured as number of days · mechanically ventilated adults with need for aerosol bronchodilator therapy

Adverse changes to haemodynamic observations Measured as a change in heart rate (beats per minute) Assessed before treatment and 30 minutes after the end of each modality of administration · mechanically ventilated adults with need for aerosol bronchodilator therapy

Mortality · bleeding patients or at risk of severe bleeding

Incidence of allogenic blood transfusion Proportion of participants transfused with RBC, FFP, PLT and/or cryo · bleeding patients or at risk of severe bleeding

Thrombotic episodes (arterial and venous graft occlusion, pulmonary embolus, deep venous thrombosis) Proportion with event · bleeding patients or at risk of severe bleeding

Intensive care unit (ICU) stay Duration of stay (hours) · bleeding patients or at risk of severe bleeding

Re‐operation due to persistent bleeding Events during admission · bleeding patients or at risk of severe bleeding

Catheter‐related infectious complications ‐ Exit site infection · cancer patients

Immediate mechanical complications ‐ Total mechanical complications · critically ill patients

Immediate mechanical complications ‐ Major mechanical complications · critically ill patients

Catheter‐related infectious complications ‐ Catheter colonization · critically ill patients who were expected to require support with renal replacement therapy

Catheter‐related infectious complications ‐ Catheter related bloodstream infection · critically ill patients who were expected to require support with renal replacement therapy

Catheter‐related infectious complication ‐ Subgroup Analysis for the effect of BMI on catheter colonization ‐ Highest BMI tercile (>28.4) · critically ill patients who were expected to require support with renal replacement therapy

Catheter‐related thrombotic complications ‐ Symptomatic deep venous thrombosis · critically ill patients who were expected to require support with renal replacement therapy

Catheter‐related thrombotic complications ‐ Catheter related thrombosis · critically ill patients who were expected to require support with renal replacement therapy

Immediate mechanical complications ‐ Total mechanical complications · critically ill patients who were expected to require support with renal replacement therapy

Immediate mechanical complications ‐ Major mechanical complications · critically ill patients who were expected to require support with renal replacement therapy

Catheter‐related infectious complications ‐ Port‐related bacteraemia and/or pocket infections · cancer patients

Catheter‐related thrombotic complications · cancer patients

Immediate mechanical complications ‐ Total mechanical complications · cancer patients

Immediate mechanical complications ‐ Major mechanical complications · cancer patients