Cochrane · systematic review · CD008863
Metered dose inhalers versus nebulizers for aerosol bronchodilator delivery for adult patients receiving mechanical ventilation in critical care units
Holland, A, Smith, F, Penny, K, et al. · Cochrane Database of Systematic Reviews · 2013 · Cochrane Library
Emergency and Critical CareAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
4
current version
GRADE rated
2
No studies
2
Included studies
NR
No studies 2 · 50%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 2 · 50%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Comparison
Population: mechanically ventilated adults with need for aerosol bronchodilator therapy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Reduction in airway resistance Measured as a reduction in additional effective resistance (ΔRrs) and interrupter resistance (Rint) Assessed before treatment and 30 minutes after the end of each modality of administration | no estimate extracted | 2 studies · 28 participants | Moderate Downgraded: risk of bias, imprecision |
Mortality during critical care unit admission Measured using mortality rate in intervention and comparison groups During critical care admission | no estimate extracted | NR | No studies |
Duration of mechanical ventilation Measured as number of days | no estimate extracted | NR | No studies |
Adverse changes to haemodynamic observations Measured as a change in heart rate (beats per minute) Assessed before treatment and 30 minutes after the end of each modality of administration | no estimate extracted | 2 studies · 28 participants | Moderate Downgraded: risk of bias, imprecision |