Cochrane · systematic review · CD003588
Optimal timing for intravascular administration set replacement
Ullman, AJ, Cooke, ML, Gillies, D, et al. · Cochrane Database of Systematic Reviews · 2013 · Cochrane Library
Emergency and Critical CareAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 5 · 83.3%Moderate 1 · 16.7%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Primary analysis: less versus more frequent for intravenous administration set replacement
Population: patients with intravenous administration set replacement
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Catheter‐related BSI as defined using criteria specified by Maki 2006; Mermel 2009; and O'Grady 2002 Primary analysis: less vs more frequent | RR 1.06 [0.66, 1.68] | 8 studies · 1794 participants | Low Downgraded: risk of bias, imprecision |
Infusate‐related BSI as defined using criteria specified by O'Grady 2002 Primary analysis: less vs more frequent | RR 0.69 [0.31, 1.51] | 11 studies · 1847 participants | Low Downgraded: risk of bias, imprecision |
Infusate colonization any positive quantitative culture of infusate Primary analysis: less vs more frequent | RR 1.15 [0.7, 1.86] | 8 studies · 1549 participants | Low Downgraded: risk of bias, imprecision |
Catheter colonization any positive semiquantitative or quantitative culture from the distal catheter segment Primary analysis: less vs more frequent | RR 1.08 [0.94, 1.24] | 4 studies · 1448 participants | Moderate Downgraded: risk of bias |
All‐cause BSI any positive blood culture drawn from a peripheral vein taken whilst the IVD is in situ, or within 48 hours of removal (O'Grady 2002) Primary analysis: less vs more frequent | RR 0.82 [0.48, 1.4] | 6 studies · 2297 participants | Low Downgraded: risk of bias, imprecision |
Mortality Primary analysis: less vs more frequent | RR 1.85 [1.01, 3.38] | 2 studies · 1355 participants | Low Downgraded: risk of bias, indirectness |