Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,103 questions · 1,157 findings · 177 reviews · Headline outcomes only

No studies found 291 · 25.2%GRADE not reported 85 · 7.3%Very low 317 · 27.4%Low 258 · 22.3%Moderate 169 · 14.6%High 37 · 3.2%

Intervention not reported

Conversion to open cholecystectomy · patients with laparoscopic cholecystectomy.

It is very uncertain whether the intervention changes conversion to open cholecystectomy (very low certainty).

1 finding from 1 review

Miniport laparoscopic cholecystectomy vs standard port laparoscopic cholecystectomy

Conversion to open cholecystectomy · patients with laparoscopic cholecystectomy.

It is very uncertain whether miniport laparoscopic cholecystectomy changes conversion to open cholecystectomy compared with standard port laparoscopic cholecystectomy (very low certainty).

1 finding from 1 review

Intervention not reported

Episodes of febrile neutropenia · patients with prevention and treatment of infectious complications in patients with acute myelogenous leukemia

The intervention showed no clear difference in episodes of febrile neutropenia (moderate certainty).

1 finding from 1 review

Radioisotopes vs placebo

Safety (AE, adverse drug reaction): thrombocytopenia Grades 3 or 4 according to National Cancer Institute · patients with metastatic bone pain

Radioisotopes showed no clear difference in thrombocytopenia III‐IV compared with placebo (low certainty).

1 finding from 1 review

Radioisotopes vs placebo

Leucocytopenia III‐IV · patients with metastatic bone pain

Radioisotopes may leads to higher leucocytopenia III‐IV compared with placebo (low certainty).

1 finding from 1 review

Intervention not reported

Average reduction in mean speed 2.3 km/h (p = 0.05) at camera sites post 1st year. Average reduction in mean speeds 1.3 km/h (‐2.6 to 0.1)post 2nd year on experimental open roads
1 finding from 1 review

Intervention not reported

Over the first 2 years of the study mean speeds fell by 1.3 km/h (‐2.6 to 0.1) and 85th percentile speeds reduced by 4.3 km/h on open roads generally,compared with the rest of the country.
1 finding from 1 review

Intervention not reported

Having controlled for season and general trends, injury crash outcomes in experimental areas relative to control areas were a net reduction of 11% (p= 0.03) in all crashes and 19% (p=0.002) in injury crashes on open roads across the region associa...

The review found no eligible studies for this question.

1 finding from 1 review

Negative pressure wound therapy vs conventional open wound healing

Time to complete healing · adults with open wounds after surgery for sacrococcygeal pilonidal sinus disease

It is very uncertain whether topical negative pressure wound therapy changes time to wound healing (days) compared with conventional open wound healing (very low certainty).

1 finding from 1 review

Negative pressure wound therapy vs conventional open wound healing

Proportion of wounds healed · adults with open wounds after surgery for sacrococcygeal pilonidal sinus disease

It is very uncertain whether topical negative pressure wound therapy changes proportion of wounds healed at 30 days compared with conventional open wound healing (very low certainty).

3 findings from 1 review

Negative pressure wound therapy vs conventional open wound healing

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · adults with open wounds after surgery for sacrococcygeal pilonidal sinus disease

The review found no eligible studies for this question.

1 finding from 1 review