Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,087 questions · 2,360 findings · 390 reviews

No studies found 224 · 9.5%GRADE not reported 603 · 25.6%Very low 555 · 23.5%Low 548 · 23.2%Moderate 312 · 13.2%High 118 · 5%

Early warning signs training and treatment as usual vs treatment

Clinical response: mental state ‐ relapse ‐ medium term Relapse rate · patients with schizophrenia

It is very uncertain whether early warning signs training and treatment as usual changes relapse: Rate of relapse compared with treatment (very low certainty).

1 finding from 1 review

Early warning signs training and treatment as usual vs treatment

Service use: Time to re‐hospitalisation · patients with schizophrenia

It is very uncertain whether early warning signs training and treatment as usual changes service use: Time to re‐hospitalisation compared with treatment (very low certainty).

1 finding from 1 review

Early intervention (mobilization or active exercise) vs usual care

Physical function ‐ return to independent functional status at hospital discharge Defined as ability to perform 6 ADLs (bathing, dressing, eating, grooming, transferring from bed to chair, using the toilet) and walk independently, · critically ill, mechanically ventilated adults

Early intervention (mobilization or active exercise) may leads to higher physical function ‐ return to independent functional status at… compared with usual care (low certainty).

1 finding from 1 review

Early intervention (mobilization or active exercise) vs usual care

Physical function · critically ill, mechanically ventilated adults
3 findings from 1 review

Early intervention (mobilization or active exercise) vs usual care

Physical performance · critically ill, mechanically ventilated adults
4 findings from 1 review
Show 1 more finding

Early intervention (mobilization or active exercise) vs usual care

Adverse events Proportion of participants with one or more events, or proportion of intervention sessions where an event occurred (falls, accidental dislodgement of attachments, haemodynamic instability, oxygen desaturation or any other adverse ev... · critically ill, mechanically ventilated adults
1 finding from 1 review

Early extraction of a compromised first permanent molar vs Contralateral non-extraction side (same patient)

Development and eruption of the second permanent molar · Children aged 5 to 15 years with a compromised first permanent molar

Root closure and eruption of the second permanent molar appeared accelerated on the extraction side in a single case-control study; ungraded and not statistically tested.

1 finding from 1 review

Early extraction of a compromised first permanent molar vs Teeth in the same arch/patient with the first permanent molar present

Caries and/or fillings in adjacent teeth · Children aged 5 to 15 years with a compromised first permanent molar

One study found fewer decayed or filled proximal surfaces but more decayed or filled occlusal surfaces in arches with an extracted first permanent molar; ungraded.

1 finding from 1 review

Early extraction of a compromised first permanent molar vs Non-extraction (retained first permanent molar) or contralateral non-extraction side

Spontaneous space closure · Children aged 5 to 15 years with a compromised first permanent molar

Early extraction of a compromised first permanent molar is followed by variable spontaneous closure of the post-extraction space (about 45.5% to 85.2% of cases); certainty was not GRADE-rated (Shekelle category III).

1 finding from 1 review

Early childhood caries (ECC) vs Caries-free primary dentition

Caries development in permanent teeth · School children and adolescents (6-18 years) followed from primary dentition (baseline examination before 72 months of age)

Early childhood caries increases the likelihood of caries in permanent teeth roughly three-fold, but the certainty of evidence is very low (OR 3.22, 95% CI 2.80 to 3.71).

1 finding from 1 review

Early warning systems (EWS) and rapid response systems (RRS) vs usual care

Hospital mortality – non‐randomised studies ( · adult on acute hospital wards at risk of clinical deterioration
2 findings from 1 review

Early warning systems (EWS) and rapid response systems (RRS) vs usual care

Length of hospital stay · adult on acute hospital wards at risk of clinical deterioration

The review found no eligible studies for this question.

2 findings from 1 review

Early warning systems (EWS) and rapid response systems (RRS) vs usual care

Adverse events (unexpected cardiac or respiratory arrest) – non‐randomised studies ( · adult on acute hospital wards at risk of clinical deterioration
2 findings from 1 review

Early warning systems (EWS) and rapid response systems (RRS) vs usual care

Composite outcome – randomised trials Composite outcome of incidence (events divided by number of eligible participants admitted to the hospital during the study period) of cardiac arrests without a pre‐existing NFR order, unplanned ICU admissions... · adult on acute hospital wards at risk of clinical deterioration
1 finding from 1 review

Early warning systems (EWS) and rapid response systems (RRS) vs usual care

Composite outcome – non‐randomised studies Composite endpoint of cardiopulmonary arrest, unplanned ICU admission or death per 1000 admitted patients ( · adult on acute hospital wards at risk of clinical deterioration
1 finding from 1 review