Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

542 questions · 578 findings · 107 reviews

No studies found 32 · 5.5%GRADE not reported 76 · 13.1%Very low 155 · 26.8%Low 150 · 26%Moderate 144 · 24.9%High 21 · 3.6%

Intervention not reported

Adverse effects Defined as deaths, hospitalisations, congenital abnormalities and life‐threatening conditions requiring an immediate hospital visit Assessed at 12 and 18 months of age · children aged 6 to 23 months

The intervention showed no clear difference in adverse effects Defined as deaths, hospitalisations, congenital… (moderate certainty).

1 finding from 1 review

Antifibrinolytic therapy (tranexamic acid or epsilon aminocaproic acid) vs Placebo, no intervention or usual care (with or without placebo)

Number of immediate (less than 24 hours) and delayed (24 hours to 10 days) postoperative bleeding episodes requiring intervention · People with haemophilia (A or B) undergoing minor oral surgery or dental extractions

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

4a. Procedural crying (during and immediately after the vaccination procedure) · infants aged approximately 2 to 6 months undergoing vaccination in the anterolateral thigh with a DTwP combination vaccine
1 finding from 1 review

Intervention not reported

4a. Procedural crying (during and immediately after the vaccination procedure) (not measured) · infants aged approximately 2 to 6 months undergoing vaccination in the anterolateral thigh with a DTwP‐Hib vaccine

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

4a. Procedural crying (during and immediately after the vaccination procedure) (not measured) · infants aged approximately 2 to 6 months undergoing vaccination in the anterolateral thigh with a DTwP‐Hib vaccine

The review found no eligible studies for this question.

1 finding from 1 review

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA) mouthwash/solution (SoF eligibility: TXA or EACA; all included trials used topical TXA) vs Placebo mouthwash

Number of immediate (less than 24 hours) and delayed (24 hours to 10 days) postoperative bleeding episodes requiring intervention · People on continuous VKA treatment undergoing minor oral surgery or dental extractions (eligibility included DOACs and all ages; all four…

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA)… led to lower number of immediate and delayed postoperative bleeding episodes… compared with placebo (placebo solution/mouthwash); GRADE not reported.

1 finding from 1 review

Resorbable (bioresorbable) plates or screws for fixation vs Titanium plates or screws for fixation

Postoperative pain during the immediate recovery period (VAS 0 to 10) · Adults (>16 years old) undergoing orthognathic surgery

It is very uncertain whether resorbable (bioresorbable) plates or screws for fixation changes postoperative pain during the immediate recovery period (VAS 0 to 10) compared with titanium plates or screws for fixation (very low certainty).

1 finding from 1 review

Intervention not reported

Immediate change in level in year 2000 (noise level at work as PEL dose in dB(A); range 0 to 6400, log scale) · workers with noise exposure
1 finding from 1 review

(ITS) Safe blood collection systems vs regular systems

Needlestick injuries · preventing percutaneous exposure injuries caused by needles in healthcare personnel

It is very uncertain whether (RCT) Safe blood collection systems changes needlestick injuries immediate compared with regular systems (very low certainty).

1 finding from 1 review

Resorbable (bioresorbable) plates or screws for fixation vs Titanium plates or screws for fixation

Swelling (mean) · Adults (>16 years old) undergoing orthognathic surgery
1 finding from 1 review
  • Resorbable versus titanium plates for orthognathic surgery 2017 · Cochrane All outcomes
    Up to 3 years postoperatively
    Though Cheung 2004 reported the presence of postoperative swelling, it was only noted in conjunction with infection and pus discharge; assessment of this outcome did not include the use of photography or digital…
    1 study · 60 participants
    GRADE not reported

Intervention not reported

Subjective memory measures (immediate outcome) · patients with memory deficits following stroke
1 finding from 1 review

Intervention not reported

Objective memory measures (immediate outcome) ‐ comprehensive batteries · patients with memory deficits following stroke
1 finding from 1 review