Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

662 questions · 720 findings · 164 reviews

No studies found 177 · 24.6%GRADE not reported 126 · 17.5%Very low 144 · 20%Low 139 · 19.3%Moderate 107 · 14.9%High 27 · 3.8%

Fluorides combined with CPP-ACP vs Fluorides alone (monotherapy)

Visual inspection scores · Patients with early caries lesions in permanent teeth (non-fluoridated water area)

Two trials reported visual inspection scores but could not be pooled (different criteria, missing standard deviations) and gave inconsistent findings, so no quantitative conclusion could be drawn.

1 finding from 1 review

Standard care plus IV tranexamic acid vs placebo or usual care

Hysterectomy to control bleeding · women with primary postpartum haemorrhage following vaginal or caesarean birth

Standard care plus IV tranexamic acid showed no clear difference in surgical intervention to control bleeding: Hysterectomy compared with placebo or standard care alone (high certainty).

1 finding from 1 review

Standard care plus IV tranexamic acid vs placebo or usual care

Side effects of the intervention: Any maternal vascular occlusive event · women with primary postpartum haemorrhage following vaginal or caesarean birth

Standard care plus IV tranexamic acid showed no clear difference in side effects of the intervention: Any maternal vascular occlusive… compared with placebo or standard care alone (moderate certainty).

1 finding from 1 review

Intravenous immunoglobulin with or without standard care vs placebo or usual care

Significant disability assessed using Liverpool Outcome Score RR (M‐H, random‐effects analysis, 95% CI) · children with acute encephalitis

It is very uncertain whether intravenous immunoglobulin with or without standard care changes significant disability assessed using Liverpool Outcome Score RR… compared with standard care alone or placebo (very low certainty).

1 finding from 1 review

Intravenous immunoglobulin with or without standard care vs placebo or usual care

Serious adverse events Analysis 11.2 · children with acute encephalitis

It is very uncertain whether intravenous immunoglobulin with or without standard care changes ≥ 1 serious adverse event RR (M‐H, random‐effects analysis, 95% CI) compared with standard care alone or placebo (very low certainty).

1 finding from 1 review