Cochrane · systematic review · CD012597
Saline irrigation for allergic rhinitis
Head, K, Snidvongs, K, Glew, S, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
ENTAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
13
current version
GRADE rated
11
No studies
2
Included studies
NR
No studies 2 · 15.4%Ungraded 0 · 0%Very low 7 · 53.8%Low 4 · 30.8%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Saline versus no saline treatment for allergic rhinitis
Population: allergic rhinitis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Disease severity score (up to 4 weeks) Saline vs no saline treatment | no estimate extracted | NR | Low Downgraded: risk of bias, inconsistency |
Disease severity score (4 weeks to 6 months) Saline vs no saline treatment | no estimate extracted | NR | Low Downgraded: risk of bias, inconsistency |
Individual symptom scores ‐ not measured Saline vs no saline treatment | no estimate extracted | NR | No studies |
Epistaxis Saline vs no saline treatment | no estimate extracted | NR | Low Downgraded: risk of bias, imprecision, inconsistency |
Disease‐specific HRQL Saline vs no saline treatment | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
Disease‐specific HRQL ‐ 4 weeks to 6 months Saline vs no saline treatment | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
Other adverse effects: local irritation Saline vs no saline treatment | no estimate extracted | NR | Low Downgraded: risk of bias, imprecision, inconsistency |
Saline irrigation plus pharmacological treatment versus pharmacological treatment alone for allergic rhinitis
Population: allergic rhinitis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Disease severity score (up to 4 weeks) Saline irrigation plus pharmacological treatment vs pharmacological treatment alone | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
Disease severity score (4 weeks to 6 months) Saline irrigation plus pharmacological treatment vs pharmacological treatment alone | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
Individual symptom scores ‐ not measured Saline irrigation plus pharmacological treatment vs pharmacological treatment alone | no estimate extracted | NR | No studies |
Adverse effects ‐ epistaxis № of participants: 58 (2 RCTs) (18 children; 40 adults) Saline irrigation plus pharmacological treatment vs pharmacological treatment alone | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
Health‐related quality of life (4 weeks to 6 months) Saline irrigation plus pharmacological treatment vs pharmacological treatment alone | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
Other adverse effects: local irritation Saline irrigation plus pharmacological treatment vs pharmacological treatment alone | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |