Findings

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Evidence found and GRADE certainty

2,890 questions · 3,917 findings · 272 reviews · Oral Health

No studies found 429 · 11%GRADE not reported 2,657 · 67.8%Very low 512 · 13.1%Low 219 · 5.6%Moderate 80 · 2%High 20 · 0.5%

Individually designed, patient-centred preventive programme: dietary counselling (snacking timing, regular meals, fermentable carbohydrates) plus toothbrushing counselling, delivered by trained dental hygienists (a multi-intervention) vs Basic prevention offered as standard in public dental clinics

Eating warm meals more than twice per day · Children aged 11 to 12 years with at least one active initial caries lesion, screened in a town in Finland
1 finding from 1 review

Individually designed, patient-centred preventive programme: dietary counselling (snacking timing, regular meals, fermentable carbohydrates) plus toothbrushing counselling, delivered by trained dental hygienists (a multi-intervention) vs Basic prevention offered as standard in public dental clinics

Drinking sports drinks no more than once per week · Children aged 11 to 12 years with at least one active initial caries lesion, screened in a town in Finland
1 finding from 1 review

Individually designed, patient-centred preventive programme: dietary counselling (snacking timing, regular meals, fermentable carbohydrates) plus toothbrushing counselling, delivered by trained dental hygienists (a multi-intervention) vs Basic prevention offered as standard in public dental clinics

Using xylitol products more than 3 times per day · Children aged 11 to 12 years with at least one active initial caries lesion, screened in a town in Finland

Individually designed, patient-centred preventive programme: dietary… led to higher using xylitol products more than 3 times per day compared with basic prevention offered as standard in public dental clinics; GRADE not reported.

1 finding from 1 review

Preoperative ibuprofen vs placebo

Postoperative pain (continuous measure: self report using visual analogue scale) · Children and adolescents having orthodontic separator placement (without local anaesthetic)

Preoperative ibuprofen may leads to lower postoperative pain (continuous measure: self report using visual… compared with placebo (low certainty).

1 finding from 1 review

Preoperative ibuprofen vs placebo

Adverse events · Children and adolescents having orthodontic separator placement (without local anaesthetic)
1 finding from 1 review

Electronic cigarette use vs Non-smokers (non-users)

Oral candidiasis prevalence · Adult e-cigarette (ENDS) users (general oral health; predominantly natural dentition)

E-cigarette users may have a higher prevalence of oral Candida colonization than non-smokers (narrative synthesis; ungraded).

1 finding from 1 review

Secondary (passive/secondhand) smoking exposure during childhood vs No secondary smoking exposure

Caries prevalence (early childhood caries) · Preschool children aged <=71 months (caries outcome assessed at 3-6 years)

Preschool children exposed to secondary smoking have higher odds of caries prevalence (OR 1.77), but the cross-sectional evidence is very uncertain (very low certainty).

2 findings from 1 review

Fixed orthodontic treatment with fixed (multibracket) appliances (exposure) vs None (single-group prevalence/incidence estimate)

Prevalence of ICLs (mean number of lesions per subject) · Patients (permanent dentition) during or after fixed orthodontic treatment with fixed (multibracket) appliances

Patients had on average about 2.24 ICLs per subject during/after fixed orthodontic treatment (95% CI 1.79-2.70; very low certainty; very high heterogeneity).

1 finding from 1 review

Fixed orthodontic treatment with fixed (multibracket) appliances (exposure) vs None (single-group prevalence/incidence estimate)

Association between orthodontic treatment duration and ICLs prevalence · Patients (permanent dentition) during or after fixed orthodontic treatment with fixed (multibracket) appliances

ICLs prevalence increased with longer orthodontic treatment duration (meta-regression P=.01; ungraded).

1 finding from 1 review

Extraction of the mandibular permanent first molar vs Not applicable (single-group prevalence)

Rotation of the mandibular second premolar · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)

After mandibular first molar extraction, the second premolar was rotated in about 60% of cases (2 studies; very imprecise; not GRADE-rated).

1 finding from 1 review

rs10974056 effect allele A (intron variant in GLIS3, chr9:3,889,264) vs Non-effect allele C

Dental caries · Adults from Japanese and European cohorts (present-study Japanese direct-to-consumer cohort + GLIDE consortium and UK Biobank European…

Meta-analysis identified a novel genome-wide-significant locus for dental caries at rs10974056 in GLIS3 (P=3.93E-08); ungraded.

1 finding from 1 review

Extraction of the mandibular permanent first molar vs Not applicable (single-group prevalence)

Rotation of the mandibular first premolar · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)

After mandibular first molar extraction, the first premolar was rotated in about 38% of cases (2 studies; very imprecise; not GRADE-rated).

1 finding from 1 review

Fixed orthodontic treatment with fixed (multibracket) appliances (exposure) vs None (single-group prevalence/incidence estimate)

Prevalence of ICLs (proportion of tooth surfaces affected) · Patients (permanent dentition) during or after fixed orthodontic treatment with fixed (multibracket) appliances

About 22% of tooth surfaces showed ICLs during/after fixed orthodontic treatment (pooled 0.22, 95% CI 0.14-0.33; very low certainty; extreme heterogeneity).

1 finding from 1 review

Fixed orthodontic treatment with fixed (multibracket) appliances (exposure) vs None (single-group prevalence/incidence estimate)

Prevalence of ICLs (proportion of subjects affected) · Patients (permanent dentition) during or after fixed orthodontic treatment with fixed (multibracket) appliances

Around 57% of patients had ICLs during or after fixed orthodontic treatment (pooled prevalence 0.57, 95% CI 0.48-0.65; very low certainty; very high heterogeneity).

1 finding from 1 review

rs4801882 effect allele G (intron variant in SIGLEC5, chr19:52,127,053) vs Non-effect allele A

Dental caries · Adults from Japanese and European cohorts (present-study Japanese direct-to-consumer cohort + GLIDE consortium and UK Biobank European…

Meta-analysis identified a novel genome-wide-significant locus for dental caries at rs4801882 in SIGLEC5 (P=1.71E-08); ungraded.

1 finding from 1 review

Fluoride toothpaste vs Not applicable (single-group prevalence)

Fluoride toothpaste use prevalence (among children with caries) · Children with dental caries (deciduous and/or permanent dentition) in low- and middle-income countries

About 39% of children with caries in LMICs used fluoride toothpaste (pooled prevalence 0.391, 95% CI 0.166 to 0.644; 2 studies; not GRADE-rated).

1 finding from 1 review

Tranexamic acid (AMCA cones) vs Placebo (lactose cones)

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Tranexamic acid (AMCA cones) showed no clear difference in presence of dry socket compared with placebo (lactose cones); GRADE not reported.

1 finding from 1 review

Apernyl (acetylsalicylic acid pellet) vs placebo

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Apernyl (acetylsalicylic acid pellet) showed no clear difference in presence of dry socket compared with placebo; GRADE not reported.

1 finding from 1 review

Caries assessment at dentine threshold (cavitation into dentine) vs None (descriptive prevalence review; subgroup analyses by urban/rural status, country and year)

Dental caries prevalence · European adolescents aged 12–19 years

Caries prevalence at the dentine threshold was about 56% (pooled 0.56, 95% CI 0.43 to 0.68; 15 studies; not GRADE-rated).

7 findings from 1 review
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