Number of patients with moderate/severe pain (1 hour postoperatively) · children undergoing surgery
Nalbuphine showed no clear difference in number of patients with moderate/severe pain (1 hour postoperatively) compared with morphine (low certainty).
2 findings from 1 review
Number requiring additional analgesia required postoperatively ‐ moderate quality studies · patients with postoperative pain
High dose clonidine may leads to lower number requiring additional analgesia required postoperatively ‐… compared with low dose clonidine (low certainty).
1 finding from 1 review
Inflammation: participants with no swelling at 72 hours (canakinumab 150 mg) Assessed by the investigator as no swelling, mild/palpable, moderate/visible, severe/bulging beyond the joint margins · acute gout
Canakinumab probably leads to higher inflammation: participants with no swelling at 72 hours (canakinumab… compared with triamcinolone acetonide (moderate certainty).
1 finding from 1 review
Intervention not reported
"Moderate" benefit At least 30% reduction in pain · neuropathic pain (5 studies in painful diabetic neuropathy and polyneuropathy)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
Patient Global Impression of Change much or very much improved (patient global evaluation of pain relief complete, good or moderate) · neuropathic pain (6 studies in central neuropathic pain due to multiple sclerosis, spinal cord injury, polyneuropathy, central post‐stroke…
1 finding from 1 review
Intervention not reported
"Moderate" benefit At least 30% reduction in pain · adults with peripheral neuropathic pain conditions
1 finding from 1 review
Intervention not reported
Patient Global Impression of Change much or very much improved (PGPR "complete", "a lot", or "moderate") · adults with neuropathic pain (3 studies in painful diabetic neuropathy and postherpetic neuralgia)
1 finding from 1 review
Moderate soft tissue deformity · Adults (16 to 68 years) with mandibular fractures excluding condylar involvement
2 mm titanium plates showed no clear difference in moderate soft tissue deformity compared with 2.5 mm bioresorbable plates; GRADE not reported.
1 finding from 1 review
Intervention not reported
Moderate dose SSRI versus placebo Luteal or continuous administration · women with premenstrual syndrome
1 finding from 1 review
Intervention not reported
Moderate dose SSRI versus placebo Luteal administration · women with premenstrual syndrome
1 finding from 1 review
Intervention not reported
Moderate dose SSRI versus placebo Continuous administration · women with premenstrual syndrome
1 finding from 1 review
Intervention not reported
Moderate dose SSRI versus placebo Luteal administration2 · women with premenstrual syndrome
1 finding from 1 review
At least 30% reduction in pain · adults with chronic low‐back pain
Strong opioids probably leads to higher at least 30% of pain relief or moderate relief compared with placebo (moderate certainty).
1 finding from 1 review
Participant‐reported pain relief of 30% or greater · neuropathic pain (two studies found in painful diabetic neuropathy, and one in lumbar radiculopathy)
1 finding from 1 review
Moderate exacerbations (course of antibiotics or oral steroids) · patients with chronic obstructive pulmonary disease
Long‐acting beta2‐agonists probably leads to lower moderate exacerbations (course of antibiotics or oral steroids) compared with placebo (moderate certainty).
1 finding from 1 review
Moderate‐to‐severe exacerbations (rate) · patients with chronic obstructive pulmonary disease
Long‐acting beta2‐agonists showed no clear difference in severe/moderate exacerbations (hospitalisation or course of… compared with placebo (moderate certainty).
1 finding from 1 review
Proportion of participants with moderate to severe pain 72 hours to 14 days after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or periapical…
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
0 studies
No studies found
Proportion of participants with moderate to severe pain 72 hours to 14 days after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or periapical…
Sodium hypochlorite 5.25% showed no clear difference in proportion of participants with moderate to severe pain 72 hours to… compared with normal saline; GRADE not reported.
1 finding from 1 review
Proportion of participants with moderate to severe pain up to 6 hours after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or periapical…
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
0 studies
No studies found
Proportion of participants with moderate to severe pain 72 hours to 14 days after the procedure · Patients aged 14 to 78 years with mature permanent teeth (fully formed roots), single or multi-rooted, with pulpal or periapical…
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
0 studies
No studies found