Findings

What do systematic reviews say?

4,345 questions · 4,525 findings · 483 reviews

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No studies found 1,024 · 22.6%GRADE not reported 388 · 8.6%Very low 1,172 · 25.9%Low 1,227 · 27.1%Moderate 576 · 12.7%High 138 · 3%

Low tidal volume vs high tidal volume

Barotrauma (pneumothorax) · adults (aged > 16 years) without acute lung injury needing mechanical positive pressure ventilation during their surgery and undergoing…

It is very uncertain whether low tidal volume changes barotrauma: pneumothorax compared with high tidal volume (very low certainty).

1 finding from 1 review

Intraoperative use of low volume ventilation to decrease postoperative mortality, mechanical ventilation, lengths of… 2018 · Cochrane Headline outcomes only
RR 1.77 [0.52, 5.99]
5 studies · 708 participants
Very low

NSAIDs vs placebo or no treatment

Death (all causes) · adults with normal kidney function undergoing surgery

It is very uncertain whether nonsteroidal anti‐inflammatory drugs (NSAIDs) changes death (all causes) compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Effects of peri‐operative nonsteroidal anti‐inflammatory drugs on post‐operative kidney function for adults with… 2018 · Cochrane Headline outcomes only
RR 1.44 [0.19, 11.12]
2 studies · 312 participants
Very low

NSAIDs vs placebo or no treatment

Length of hospital stay · adults with normal kidney function undergoing surgery

It is very uncertain whether nonsteroidal anti‐inflammatory drugs (NSAIDs) changes length of hospital stay compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Effects of peri‐operative nonsteroidal anti‐inflammatory drugs on post‐operative kidney function for adults with… 2018 · Cochrane Headline outcomes only
MD 0.12
3 studies · 410 participants
Very low

Concomitant (concurrent) chemoradiotherapy vs radical surgery

Overall survival (5‐year) · women (18 years and older) diagnosed with stage IB2 cervical cancer

1 finding from 1 review

Type II or type III radical hysterectomy compared to chemoradiotherapy as a primary intervention for stage IB2… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Concomitant (concurrent) chemoradiotherapy vs radical surgery

Progression‐free survival (PSF) · women (18 years and older) diagnosed with stage IB2 cervical cancer

The review found no eligible studies for this question.

1 finding from 1 review

Type II or type III radical hysterectomy compared to chemoradiotherapy as a primary intervention for stage IB2… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Concomitant (concurrent) chemoradiotherapy vs radical surgery

Recurrence · women (18 years and older) diagnosed with stage IB2 cervical cancer

It is very uncertain whether chemoradiotherapy changes recurrence compared with radical surgery (very low certainty).

1 finding from 1 review

Type II or type III radical hysterectomy compared to chemoradiotherapy as a primary intervention for stage IB2… 2018 · Cochrane Headline outcomes only
OR 2.26 [1.24, 4.14]
1 study · 215 participants
Very low

Concomitant (concurrent) chemoradiotherapy vs radical surgery

Adverse events: lymphoedema · women (18 years and older) diagnosed with stage IB2 cervical cancer

The review found no eligible studies for this question.

1 finding from 1 review

Type II or type III radical hysterectomy compared to chemoradiotherapy as a primary intervention for stage IB2… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Dexamethasone vs control

Postoperative wound or systemic infection · participants undergoing surgery

Dexamethasone showed no clear difference in postoperative wound or systemic infection compared with control (moderate certainty).

1 finding from 1 review

Adverse side effects of dexamethasone in surgical patients 2018 · Cochrane Headline outcomes only
OR 1.01 [0.8, 1.27]
26 studies · 4603 participants
Moderate

Dexamethasone vs control

Delayed wound healing · participants undergoing surgery

Dexamethasone showed no clear difference in delayed wound healing compared with control (low certainty).

1 finding from 1 review

Adverse side effects of dexamethasone in surgical patients 2018 · Cochrane Headline outcomes only
OR 0.99 [0.28, 3.43]
8 studies · 642 participants
Low

Dexamethasone vs control

Glycaemic response ‐ change from baseline to 2 to 12 hours postoperatively in patients without diabetes · participants undergoing surgery

1 finding from 1 review

Adverse side effects of dexamethasone in surgical patients 2018 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 595 participants
Low

Blue‐light filtering intraocular lenses (IOL) vs non blue‐light filtering IOL

Change in distance BCVA, between baseline and 12 months · adults undergoing cataract surgery with IOL implantation

1 finding from 1 review

Blue‐light filtering intraocular lenses (IOLs) for protecting macular health 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 131 participants
Moderate

Blue‐light filtering intraocular lenses (IOL) vs non blue‐light filtering IOL

BCVA: loss of 15 or more ETDRS letters · adults undergoing cataract surgery with IOL implantation

1 finding from 1 review

Blue‐light filtering intraocular lenses (IOLs) for protecting macular health 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 63 participants
Very low

Blue‐light filtering intraocular lenses (IOL) vs non blue‐light filtering IOL

Contrast sensitivity function, measured in log Contrast Sensitivity at six months · adults undergoing cataract surgery with IOL implantation

The review found no eligible studies for this question.

1 finding from 1 review

Blue‐light filtering intraocular lenses (IOLs) for protecting macular health 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Blue‐light filtering intraocular lenses (IOL) vs non blue‐light filtering IOL

Colour discrimination, measured as the proportion of eyes that had a measurable loss from baseline using Farnsworth‐Munsell 100‐hue colour test score under photopic conditions at six months · adults undergoing cataract surgery with IOL implantation

The review found no eligible studies for this question.

1 finding from 1 review

Blue‐light filtering intraocular lenses (IOLs) for protecting macular health 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Blue‐light filtering intraocular lenses (IOL) vs non blue‐light filtering IOL

Proportion of participants with adverse events with a probable causal link with the study interventions at six months · adults undergoing cataract surgery with IOL implantation

The review found no eligible studies for this question.

1 finding from 1 review

Blue‐light filtering intraocular lenses (IOLs) for protecting macular health 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Blue‐light filtering intraocular lenses (IOL) vs non blue‐light filtering IOL

Late AMD · adults undergoing cataract surgery with IOL implantation

1 finding from 1 review

Blue‐light filtering intraocular lenses (IOLs) for protecting macular health 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 50 participants
Very low

Blue‐light filtering intraocular lenses (IOL) vs non blue‐light filtering IOL

Proportion of eyes that developed any stage of AMD at 12 months · adults undergoing cataract surgery with IOL implantation

1 finding from 1 review

Blue‐light filtering intraocular lenses (IOLs) for protecting macular health 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 144 participants
Very low

Intervention not reported

The ability of OWSC, when seen to reach the colon on · Adults 18 yrs and over with malignant bowel obstruction (MBO) as defined by the International Conference on MBO, with no indication for…

The review found no eligible studies for this question.

1 finding from 1 review

Oral water soluble contrast for malignant bowel obstruction 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

The rate of resolution of MBO with medical management only in patients receiving OWSC compared with those not receiving it (therapeutic). · Adults 18 yrs and over with malignant bowel obstruction (MBO) as defined by the International Conference on MBO, with no indication for…

The review found no eligible studies for this question.

1 finding from 1 review

Oral water soluble contrast for malignant bowel obstruction 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Gastrointestinal adverse effects (increased abdominal pain, nausea, vomiting). · Adults 18 yrs and over with malignant bowel obstruction (MBO) as defined by the International Conference on MBO, with no indication for…

1 finding from 1 review

Oral water soluble contrast for malignant bowel obstruction 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 9 participants
Very low