Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

461 questions · 475 findings · 59 reviews · Headline outcomes only

No studies found 112 · 23.6%GRADE not reported 13 · 2.7%Very low 66 · 13.9%Low 140 · 29.5%Moderate 112 · 23.6%High 32 · 6.7%

Sodium valproate vs phenytoin monotherapy

Time to achieve 12‐month remission (seizure‐free period) Subgroup: focal onset seizures Range of · adults and children with newly‐onset focal onset or generalised tonic‐clonic seizures

Sodium valproate showed no clear difference in time to achieve 12‐month remission (seizure‐free period) Subgroup:… compared with phenytoin monotherapy (moderate certainty).

1 finding from 1 review

Oxcarbazepine vs phenytoin

Time to 12‐month remission ‐ stratified by epilepsy type ‐ generalised onset Range of · people with newly diagnosed epilepsy

Summary of findings: oxcarbazepine showed no clear difference in time to achieve 12‐month remission (seizure‐free period) Subgroup:… compared with phenytoin (secondary outcomes) (low certainty).

1 finding from 1 review

Oxcarbazepine vs phenytoin

Time to treatment failure (any reason related to treatment) Subgroup: generalised onset seizures Range of · people with newly diagnosed epilepsy

Summary of findings: oxcarbazepine showed no clear difference in time to treatment failure (any reason related to treatment)… compared with phenytoin (primary outcomes) (moderate certainty).

1 finding from 1 review

Oxcarbazepine vs phenytoin

Time to first seizure (post‐randomisation) Subgroup: generalised onset seizures Range of · people with newly diagnosed epilepsy

Summary of findings: oxcarbazepine showed no clear difference in time to first seizure (post‐randomisation) Subgroup: generalised… compared with phenytoin (secondary outcomes) (low certainty).

1 finding from 1 review

CBT plus standard care vs usual care

Mental state: General ‐ clinically important change (no improvement) · patients with schizophrenia

It is very uncertain whether COMPARISON 1: CBT+ STANDARD CARE changes mental state: General ‐ clinically important change (no improvement)… compared with STANDARD CARE ALONE (very low certainty).

1 finding from 1 review

CBT plus standard care vs usual care

Adverse events experienced at short or long term ‐ general adverse events 24 weeks' · patients with schizophrenia

It is very uncertain whether COMPARISON 1: CBT+ STANDARD CARE changes adverse events: General: any adverse event compared with STANDARD CARE ALONE (very low certainty).

1 finding from 1 review

CBT vs ALL OTHER PSYCHOLOGICAL THERAPIES

Mental state: General ‐ clinically important change (no improvement) · patients with schizophrenia

CBT showed no clear difference in mental state: General ‐ clinically important change (no improvement) compared with ALL OTHER PSYCHOLOGICAL THERAPIES (low certainty).

1 finding from 1 review

Oestrogen vs placebo or no treatment

Incontinence not improved (generic inverse variance) (women's observations) ‐ Systemic administration (any incontinence) · patients with urinary incontinence in post‐menopausal women

Oestrogen may leads to higher incontinence not improved (generic inverse variance) (women's… compared with placebo or no treatment (low certainty).

1 finding from 1 review