Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,679 questions · 1,720 findings · 335 reviews · Headline outcomes only

No studies found 192 · 11.2%GRADE not reported 75 · 4.4%Very low 526 · 30.6%Low 504 · 29.3%Moderate 305 · 17.7%High 118 · 6.9%

Extended specialised early intervention (SEI) teams vs standard SEI teams plus treatment

Service use: disengagement from services(assessment varied) · recent‐onset psychosis

Extended specialised early intervention (SEI) teams may leads to lower service use: disengagement from services(assessment varied) compared with standard SEI teams plus treatment (low certainty).

1 finding from 1 review

Extended specialised early intervention (SEI) teams vs standard SEI teams plus treatment

Service use: admission to psychiatric hospital (assessed by proportion admitted at end of treatment) · recent‐onset psychosis

Extended specialised early intervention (SEI) teams showed no clear difference in service use: admission to psychiatric hospital at end of treatment… compared with standard SEI teams plus treatment (low certainty).

1 finding from 1 review

Extended specialised early intervention (SEI) teams vs standard SEI teams plus treatment

Adverse effects/events: death ‐ all‐cause mortality(assessed by patient records) · recent‐onset psychosis

Extended specialised early intervention (SEI) teams showed no clear difference in adverse effects/events: death ‐ all‐cause mortality(assessed by… compared with standard SEI teams plus treatment (low certainty).

1 finding from 1 review

Early warning signs training and treatment as usual vs treatment

Clinical response: mental state ‐ relapse ‐ medium term Relapse rate · patients with schizophrenia

It is very uncertain whether early warning signs training and treatment as usual changes relapse: Rate of relapse compared with treatment (very low certainty).

1 finding from 1 review

Early warning signs training and treatment as usual vs treatment

Service use: Time to re‐hospitalisation · patients with schizophrenia

It is very uncertain whether early warning signs training and treatment as usual changes service use: Time to re‐hospitalisation compared with treatment (very low certainty).

1 finding from 1 review

Early intervention (mobilization or active exercise) vs usual care

Physical function ‐ return to independent functional status at hospital discharge Defined as ability to perform 6 ADLs (bathing, dressing, eating, grooming, transferring from bed to chair, using the toilet) and walk independently, · critically ill, mechanically ventilated adults

Early intervention (mobilization or active exercise) may leads to higher physical function ‐ return to independent functional status at… compared with usual care (low certainty).

1 finding from 1 review

Early intervention (mobilization or active exercise) vs usual care

Physical function · critically ill, mechanically ventilated adults
3 findings from 1 review

Early intervention (mobilization or active exercise) vs usual care

Physical performance · critically ill, mechanically ventilated adults
4 findings from 1 review
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Early intervention (mobilization or active exercise) vs usual care

Adverse events Proportion of participants with one or more events, or proportion of intervention sessions where an event occurred (falls, accidental dislodgement of attachments, haemodynamic instability, oxygen desaturation or any other adverse ev... · critically ill, mechanically ventilated adults
1 finding from 1 review

Early warning systems (EWS) and rapid response systems (RRS) vs usual care

Hospital mortality – non‐randomised studies ( · adult on acute hospital wards at risk of clinical deterioration
2 findings from 1 review

Early warning systems (EWS) and rapid response systems (RRS) vs usual care

Length of hospital stay · adult on acute hospital wards at risk of clinical deterioration

The review found no eligible studies for this question.

2 findings from 1 review

Early warning systems (EWS) and rapid response systems (RRS) vs usual care

Adverse events (unexpected cardiac or respiratory arrest) – non‐randomised studies ( · adult on acute hospital wards at risk of clinical deterioration
2 findings from 1 review