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Search review questions

Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Every word you type has to appear somewhere in the question, and the closest matches are ranked first.

Limit to evidence status or GRADE (optional)

75,239 questions in 5,342 reviews

current versions
No studies 15,213 · 20.2%Ungraded 10,323 · 13.7%Very low 17,528 · 23.3%Low 17,951 · 23.9%Moderate 11,190 · 14.9%High 3,034 · 4%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

QuestionEffectEvidenceStatus / GRADE
Knee length vs thigh length graduated compression stockings
Deep vein thrombosis (Fixed‐effect analysis) Venous duplex scan, contrast venography and fibrinogen uptake scan · patients with prevention of deep vein thrombosis1
Knee length versus thigh length graduated compression stockings for prevention of deep vein thrombosis in… (2012) · Cochrane
OR 1.55 [0.78, 3.07]3 studies · 496 participantsVery low
Knee length vs thigh length graduated compression stockings
Deep vein thrombosis (Random‐effects analysis) Venous duplex scan, contrast venography and fibrinogen uptake scan · patients with prevention of deep vein thrombosis1
Knee length versus thigh length graduated compression stockings for prevention of deep vein thrombosis in… (2012) · Cochrane
OR 1.32 [0.43, 4.06]3 studies · 496 participantsVery low
Knee length vs thigh length graduated compression stockings
Deep vein thrombosis (Risk Difference) Venous duplex scan, contrast venography and fibrinogen uptake scan · patients with prevention of deep vein thrombosis1
Knee length versus thigh length graduated compression stockings for prevention of deep vein thrombosis in… (2012) · Cochrane
no estimate extracted3 studies · 496 participantsVery low
Intervention NR
Death from any cause ( · patients with diabetes mellitus
Cinnamon for diabetes mellitus (2012) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Morbidity ( · patients with diabetes mellitus
Cinnamon for diabetes mellitus (2012) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Health‐related quality of life ( · patients with diabetes mellitus
Cinnamon for diabetes mellitus (2012) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Adverse events ( · patients with diabetes mellitus
Cinnamon for diabetes mellitus (2012) · Cochrane
no estimate extracted4 studies · 264 participantsModerate
Intervention NR
Costs ( · patients with diabetes mellitus
Cinnamon for diabetes mellitus (2012) · Cochrane
no estimate extractedNRNo studies
Intervention NR
HbA1c ( · patients with diabetes mellitus
Cinnamon for diabetes mellitus (2012) · Cochrane
no estimate extracted6 studies · 405 participantsModerate
Doxycycline+Rifampicin vs Doxycycline+Streptomycin
total treatment failure · patients with human Brucellosis
Antibiotics for treating human brucellosis (2012) · Cochrane
RR 1.91 [1.07, 3.42]7 studies · 567 participantsModerate
Doxycycline+Rifampicin vs Doxycycline+Streptomycin
Minor adverse drug reactions · patients with human Brucellosis
Antibiotics for treating human brucellosis (2012) · Cochrane
RR 1.38 [0.99, 1.92]5 studies · 473 participantsLow
Doxycycline+Rifampicin vs Quinolones+Rifampicin
total treatment failure · patients with human Brucellosis
Antibiotics for treating human brucellosis (2012) · Cochrane
OR 0.94 [0.45, 1.98]3 studies · 181 participantsModerate
Doxycycline+Rifampicin vs Quinolones+Rifampicin
Minor adverse drug reactions · patients with human Brucellosis
Antibiotics for treating human brucellosis (2012) · Cochrane
RR 1.8 [0.78, 4.18]4 studies · 296 participantsLow
Doxycycline+Streptomycin vs Doxycycline+Gentamycin
total treatment failure · patients with human Brucellosis
Antibiotics for treating human brucellosis (2012) · Cochrane
OR 1.85 [0.84, 4.08]2 studies · 345 participantsLow
Doxycycline+Streptomycin vs Doxycycline+Gentamycin
Minor adverse drug reactions · patients with human Brucellosis
Antibiotics for treating human brucellosis (2012) · Cochrane
RR 0.85 [0.6, 1.22]2 studies · 345 participantsVery low
TDF+ FTC vs placebo
HIV infection · High‐risk HIV‐uninfected individuals (including serodiscordant couples, men who have sex with men and sex workers)
Antiretroviral pre‐exposure prophylaxis (PrEP) for preventing HIV in high‐risk individuals (2012) · Cochrane
RR 0.49 [0.28, 0.85]4 studies · 8813 participantsModerate
TDF+ FTC vs placebo
Serious adverse events · High‐risk HIV‐uninfected individuals (including serodiscordant couples, men who have sex with men and sex workers)
Antiretroviral pre‐exposure prophylaxis (PrEP) for preventing HIV in high‐risk individuals (2012) · Cochrane
RR 1 [0.83, 1.19]3 studies · 6862 participantsModerate
TDF vs placebo
HIV infection · High‐risk individuals (including serodiscordant couples, men who have sex with men and sex workers)
Antiretroviral pre‐exposure prophylaxis (PrEP) for preventing HIV in high‐risk individuals (2012) · Cochrane
RR 0.33 [0.2, 0.55]2 studies · 4027 participantsModerate
TDF vs placebo
Serious adverse events · High‐risk individuals (including serodiscordant couples, men who have sex with men and sex workers)
Antiretroviral pre‐exposure prophylaxis (PrEP) for preventing HIV in high‐risk individuals (2012) · Cochrane
RR 1.03 [0.79, 1.33]1 study · 3168 participantsModerate
Technology‐mediated psychoeducation vs standard care intervention
Compliance/satisfaction: leaving the study early ‐ any reason · patients with people with schizophrenia
Information and communication technology in patient education and support for people with schizophrenia (2012) · Cochrane
RR 1.24 [0.81, 1.88]2 studies · 116 participantsVery low
Technology‐mediated psychoeducation + standard care intervention vs standard care intervention
Global state: not improved ‐ short‐term GAF · patients with people with schizophrenia
Information and communication technology in patient education and support for people with schizophrenia (2012) · Cochrane
RR 1.15 [0.86, 1.54]1 study · 56 participantsLow
Technology‐mediated psychoeducation + standard care intervention vs standard care intervention
Knowledge/insight: not improved ITAQ · patients with people with schizophrenia
Information and communication technology in patient education and support for people with schizophrenia (2012) · Cochrane
RR 1 [0.76, 1.31]1 study · 56 participantsLow
Technology‐mediated psychoeducation + standard care intervention vs standard care intervention
Quality of life · patients with people with schizophrenia
Information and communication technology in patient education and support for people with schizophrenia (2012) · Cochrane
no estimate extracted0 studies · 0 participantsUngraded
Technology‐mediated psychoeducation + standard care intervention vs standard care intervention
Needs · patients with people with schizophrenia
Information and communication technology in patient education and support for people with schizophrenia (2012) · Cochrane
no estimate extracted0 studies · 0 participantsUngraded
Technology‐mediated psychoeducation + standard care intervention vs standard care intervention
Social support · patients with people with schizophrenia
Information and communication technology in patient education and support for people with schizophrenia (2012) · Cochrane
no estimate extracted0 studies · 0 participantsUngraded
Technology‐mediated psychoeducation vs standard care intervention
Mental state: not improved ‐ short‐term BPRS · patients with people with schizophrenia
Information and communication technology in patient education and support for people with schizophrenia (2012) · Cochrane
RR 0.75 [0.56, 1]1 study · 84 participantsLow
Technology‐mediated psychoeducation vs standard care intervention
Global state: not improved ‐ short‐term GAF · patients with people with schizophrenia
Information and communication technology in patient education and support for people with schizophrenia (2012) · Cochrane
RR 1.08 [0.82, 1.42]1 study · 84 participantsLow
Technology‐mediated psychoeducation vs standard care intervention
Knowledge/insight · patients with people with schizophrenia
Information and communication technology in patient education and support for people with schizophrenia (2012) · Cochrane
no estimate extracted0 studies · 0 participantsUngraded
Technology‐mediated psychoeducation vs standard care intervention
Quality of life · patients with people with schizophrenia
Information and communication technology in patient education and support for people with schizophrenia (2012) · Cochrane
no estimate extracted0 studies · 0 participantsUngraded
Technology‐mediated psychoeducation vs standard care intervention
Needs · patients with people with schizophrenia
Information and communication technology in patient education and support for people with schizophrenia (2012) · Cochrane
no estimate extracted0 studies · 0 participantsUngraded
Technology‐mediated psychoeducation vs standard care intervention
Social support Social Network Interview · patients with people with schizophrenia
Information and communication technology in patient education and support for people with schizophrenia (2012) · Cochrane
RR 0.42 [0.04, 0.8]1 study · 60 participantsUngraded
Technology‐mediated psychoeducation + standard care intervention vs standard care intervention
Compliance/satisfaction: medication ‐ not compliant ‐ long‐term · patients with people with schizophrenia
Information and communication technology in patient education and support for people with schizophrenia (2012) · Cochrane
RR 0.45 [0.27, 0.77]1 study · 71 participantsVery low
Technology‐mediated psychoeducation + standard care intervention vs standard care intervention
Mental state: not improved ‐ short‐term BPRS · patients with people with schizophrenia
Information and communication technology in patient education and support for people with schizophrenia (2012) · Cochrane
RR 0.86 [0.63, 1.19]1 study · 56 participantsLow
Black cohosh vs placebo
Vasomotor symptoms: daily hot flush frequency · patients with menopausal symptoms
Black cohosh (Cimicifuga spp.) for menopausal symptoms (2012) · Cochrane
no estimate extracted3 studies · 393 participantsModerate
Black cohosh vs placebo
Vasomotor symptoms: hot flush intensity · patients with menopausal symptoms
Black cohosh (Cimicifuga spp.) for menopausal symptoms (2012) · Cochrane
no estimate extracted3 studies · 214 participantsModerate
Black cohosh vs placebo
Vasomotor symptoms: night sweats · patients with menopausal symptoms
Black cohosh (Cimicifuga spp.) for menopausal symptoms (2012) · Cochrane
no estimate extracted1 study · 164 participantsModerate
Black cohosh vs placebo
Menopausal Symptom Score · patients with menopausal symptoms
Black cohosh (Cimicifuga spp.) for menopausal symptoms (2012) · Cochrane
no estimate extracted4 studies · 357 participantsModerate
Black cohosh vs placebo
Adverse events · patients with menopausal symptoms
Black cohosh (Cimicifuga spp.) for menopausal symptoms (2012) · Cochrane
RR 1.04 [0.82, 1.32]2 studies · 344 participantsLow
Intervention NR
Primary outcome: Mortality · Adults (over 18 years) with requirement for an ERCP procedure with diagnostic intent
Sedative techniques for endoscopic retrograde cholangiopancreatography (2012) · Cochrane
no estimate extracted4 studies · 510 participantsModerate
Intervention NR
Primary Outcome: Hypoxaemia · Adults (over 18 years) with requirement for an ERCP procedure with diagnostic intent
Sedative techniques for endoscopic retrograde cholangiopancreatography (2012) · Cochrane
no estimate extracted4 studies · 510 participantsModerate
Intervention NR
Primary Outcome: Hypotension · Adults (over 18 years) with requirement for an ERCP procedure with diagnostic intent
Sedative techniques for endoscopic retrograde cholangiopancreatography (2012) · Cochrane
no estimate extracted4 studies · 510 participantsModerate
Intervention NR
Primary outcome: Failure to complete procedure (due to sedation‐related problems) · Adults (over 18 years) with requirement for an ERCP procedure with diagnostic intent
Sedative techniques for endoscopic retrograde cholangiopancreatography (2012) · Cochrane
no estimate extracted3 studies · 360 participantsModerate
Intervention NR
Secondary outcome: Recovery · Adults (over 18 years) with requirement for an ERCP procedure with diagnostic intent
Sedative techniques for endoscopic retrograde cholangiopancreatography (2012) · Cochrane
no estimate extracted3 studies · 359 participantsModerate
Intervention NR
Death (all cause) · HIV infected adults who meet the WHO criteria for commencing antiretroviral treatment.
Effectiveness and safety of first-line tenofovir + emtricitabine + efavirenz for patients with HIV (2012) · Cochrane
RR 0.5 [0.05, 5.46]1 study · 487 participantsLow
Intervention NR
Proportion of patients achieving and maintaining undetectable viral load, e.g. less than 400 copies/ml · HIV infected adults who meet the WHO criteria for commencing antiretroviral treatment.
Effectiveness and safety of first-line tenofovir + emtricitabine + efavirenz for patients with HIV (2012) · Cochrane
RR 1.161 study · 487 participantsLow
Intervention NR
Proportion of patients achieving and maintaining undetectable viral load, e.g. less than 50 copies/ml · HIV infected adults who meet the WHO criteria for commencing antiretroviral treatment.
Effectiveness and safety of first-line tenofovir + emtricitabine + efavirenz for patients with HIV (2012) · Cochrane
RR 1.13 [1.02, 1.25]1 study · 487 participantsLow
Intervention NR
CD4+ count · HIV infected adults who meet the WHO criteria for commencing antiretroviral treatment.
Effectiveness and safety of first-line tenofovir + emtricitabine + efavirenz for patients with HIV (2012) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Pain 10‐cm VAS scale (median · participants with osteoarthritis of the knee or hip
Doxycycline for osteoarthritis of the knee or hip (2012) · Cochrane
no estimate extracted2 studies · 524 participantsModerate
Intervention NR
Function WOMAC function (range 0 to 10) (median · participants with osteoarthritis of the knee or hip
Doxycycline for osteoarthritis of the knee or hip (2012) · Cochrane
no estimate extracted2 studies · 517 participantsModerate
Intervention NR
Minimum joint space width ( · participants with osteoarthritis of the knee or hip
Doxycycline for osteoarthritis of the knee or hip (2012) · Cochrane
no estimate extracted1 study · 361 participantsModerate