Gap finder

Search review questions

Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Every word you type has to appear somewhere in the question, and the closest matches are ranked first.

Limit to evidence status or GRADE (optional)

75,239 questions in 5,342 reviews

current versions
No studies 15,213 · 20.2%Ungraded 10,323 · 13.7%Very low 17,528 · 23.3%Low 17,951 · 23.9%Moderate 11,190 · 14.9%High 3,034 · 4%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

QuestionEffectEvidenceStatus / GRADE
Intervention NR
Weight gain · patients with diabetic neuropathy
Enhanced glucose control for preventing and treating diabetic neuropathy (2012) · Cochrane
RR 1.96 [1.81, 2.13]1 study · 10078 participantsHigh
Intervention NR
Other adverse events · patients with diabetic neuropathy
Enhanced glucose control for preventing and treating diabetic neuropathy (2012) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Annual change in peroneal nerve motor conduction velocity m/sec · patients with diabetic neuropathy
Enhanced glucose control for preventing and treating diabetic neuropathy (2012) · Cochrane
no estimate extracted4 studies · 1371 participantsHigh
Intervention NR
Annual change in median nerve motor conduction velocity · patients with diabetic neuropathy
Enhanced glucose control for preventing and treating diabetic neuropathy (2012) · Cochrane
no estimate extracted2 studies · 1241 participantsHigh
Intervention NR
Annual change in ulnar nerve motor conduction velocity · patients with diabetic neuropathy
Enhanced glucose control for preventing and treating diabetic neuropathy (2012) · Cochrane
no estimate extracted2 studies · 134 participantsModerate
Intervention NR
Annual change in vibration threshold in the feet · patients with diabetic neuropathy
Enhanced glucose control for preventing and treating diabetic neuropathy (2012) · Cochrane
no estimate extracted3 studies · 177 participantsHigh
Intervention NR
Adverse events · patients with diabetic neuropathy
Enhanced glucose control for preventing and treating diabetic neuropathy (2012) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Wide 95% CI. · patients with diabetic neuropathy
Enhanced glucose control for preventing and treating diabetic neuropathy (2012) · Cochrane
no estimate extracted1 participantsUngraded
Intervention NR
Annual incidence of clinical neuropathy: risk ratio · patients with diabetic neuropathy
Enhanced glucose control for preventing and treating diabetic neuropathy (2012) · Cochrane
no estimate extracted4 studies · 6669 participantsHigh
Intervention NR
Annual change in median nerve motor conduction velocity · patients with diabetic neuropathy
Enhanced glucose control for preventing and treating diabetic neuropathy (2012) · Cochrane
no estimate extracted1 study · 99 participantsModerate
Intervention NR
Overall quality of life change score ‐ up to 12 weeks' · Cancer survivors who have completed active cancer treatment
Exercise interventions on health‐related quality of life for cancer survivors (2012) · Cochrane
no estimate extracted11 studies · 826 participantsLow
Intervention NR
Overall social functioning change ‐ up to 12 weeks' · Cancer survivors who have completed active cancer treatment
Exercise interventions on health‐related quality of life for cancer survivors (2012) · Cochrane
no estimate extracted5 studies · 386 participantsVery low
Intervention NR
Overall social functioning change ‐ 6 months' · Cancer survivors who have completed active cancer treatment
Exercise interventions on health‐related quality of life for cancer survivors (2012) · Cochrane
no estimate extracted2 studies · 110 participantsModerate
Intervention NR
Overall quality of life change score ‐ 6 months' · Cancer survivors who have completed active cancer treatment
Exercise interventions on health‐related quality of life for cancer survivors (2012) · Cochrane
no estimate extracted2 studies · 115 participantsModerate
Intervention NR
Overall anxiety change ‐ Up to 12 weeks' · Cancer survivors who have completed active cancer treatment
Exercise interventions on health‐related quality of life for cancer survivors (2012) · Cochrane
no estimate extracted4 studies · 455 participantsLow
Intervention NR
Overall emotional well‐being/mental health change ‐ up to 12 weeks' · Cancer survivors who have completed active cancer treatment
Exercise interventions on health‐related quality of life for cancer survivors (2012) · Cochrane
no estimate extracted8 studies · 632 participantsLow
Intervention NR
Overall fatigue change ‐ Up to 12 weeks' · Cancer survivors who have completed active cancer treatment
Exercise interventions on health‐related quality of life for cancer survivors (2012) · Cochrane
no estimate extracted10 studies · 745 participantsModerate
Intervention NR
Overall fatigue change ‐ More than 12 weeks less than 6 months' · Cancer survivors who have completed active cancer treatment
Exercise interventions on health‐related quality of life for cancer survivors (2012) · Cochrane
no estimate extracted3 studies · 246 participantsLow
Intervention NR
Overall pain · Cancer survivors who have completed active cancer treatment
Exercise interventions on health‐related quality of life for cancer survivors (2012) · Cochrane
no estimate extracted4 studies · 289 participantsModerate
Intervention NR
Overall sexuality change ‐ 6 months' · Cancer survivors who have completed active cancer treatment
Exercise interventions on health‐related quality of life for cancer survivors (2012) · Cochrane
no estimate extracted2 studies · 193 participantsModerate
Intervention NR
Overall sleep disturbance · Cancer survivors who have completed active cancer treatment
Exercise interventions on health‐related quality of life for cancer survivors (2012) · Cochrane
no estimate extracted8 studies · 438 participantsModerate
Intervention NR
Death within 5 years · patients with early‐stage cervical cancer (FIGO stages IB1, IB2 or IIA)
Radiotherapy and chemoradiation after surgery for early cervical cancer (2012) · Cochrane
RR 0.84 [0.3, 2.36]2 studies · 397 participantsModerate
Intervention NR
Disease progression within 5 years · patients with early‐stage cervical cancer (FIGO stages IB1, IB2 or IIA)
Radiotherapy and chemoradiation after surgery for early cervical cancer (2012) · Cochrane
RR 0.58 [0.37, 0.91]2 studies · 397 participantsModerate
Intervention NR
Haematological adverse events (grade 3 or 4) · patients with early‐stage cervical cancer (FIGO stages IB1, IB2 or IIA)
Radiotherapy and chemoradiation after surgery for early cervical cancer (2012) · Cochrane
RR 2.38 [0.63, 9.05]2 studies · 388 participantsModerate
Intervention NR
Gastrointestinal adverse events (grade 3 or 4) · patients with early‐stage cervical cancer (FIGO stages IB1, IB2 or IIA)
Radiotherapy and chemoradiation after surgery for early cervical cancer (2012) · Cochrane
RR 7.32 [0.91, 58.82]2 studies · 388 participantsModerate
Intervention NR
Genitourinary adverse events (grade 3 or 4) · patients with early‐stage cervical cancer (FIGO stages IB1, IB2 or IIA)
Radiotherapy and chemoradiation after surgery for early cervical cancer (2012) · Cochrane
RR 2.12 [0.54, 8.37]2 studies · 388 participantsModerate
Hepatic product (HepaticAid) vs diet only (without supplement)
Re‐hospitalisation post liver transplantation [event per patient] · adult patients with malnutrition and encephalopathy before and after liver transplantation.
Nutritional interventions for liver‐transplanted patients (2012) · Cochrane
no estimate extracted1 study · 22 participantsVery low
Standard casein product (Ensure) vs diet only (without supplement)
Acute rejection [events per patient] · adult patients with malnutrition and encephalopathy before and after liver transplantation.
Nutritional interventions for liver‐transplanted patients (2012) · Cochrane
no estimate extracted1 study · 24 participantsVery low
Standard casein product (Ensure) vs diet only (without supplement)
New onset of diabetes · adult patients with malnutrition and encephalopathy before and after liver transplantation.
Nutritional interventions for liver‐transplanted patients (2012) · Cochrane
no estimate extracted1 study · 24 participantsVery low
Standard casein product (Ensure) vs diet only (without supplement)
Length of stay in hospital after liver transplantation · adult patients with malnutrition and encephalopathy before and after liver transplantation.
Nutritional interventions for liver‐transplanted patients (2012) · Cochrane
no estimate extracted1 study · 24 participantsVery low
Standard casein product (Ensure) vs diet only (without supplement)
Hepatic encephalopathy related hospitalisation · adult patients with malnutrition and encephalopathy before and after liver transplantation.
Nutritional interventions for liver‐transplanted patients (2012) · Cochrane
no estimate extracted1 study · 20 participantsVery low
Standard casein product (Ensure) vs diet only (without supplement)
Changes in grade of hepatic encephalopathy [grade 0‐4] · adult patients with malnutrition and encephalopathy before and after liver transplantation.
Nutritional interventions for liver‐transplanted patients (2012) · Cochrane
no estimate extracted1 study · 20 participantsVery low
Nutritional supplement (500ml) and standard diet vs standard diet alone
Mortality during time on waiting list (ITT) · adult patients before and after liver transplantation.
Nutritional interventions for liver‐transplanted patients (2012) · Cochrane
OR 0.24 [0.02, 1.37]1 study · 82 participantsVery low
Nutritional supplement (500ml) and standard diet vs standard diet alone
Six months mortality after liver transplantation (ITT) · adult patients before and after liver transplantation.
Nutritional interventions for liver‐transplanted patients (2012) · Cochrane
OR 0.37 [0.06, 1.77]1 study · 82 participantsVery low
Nutritional supplement (500ml) and standard diet vs standard diet alone
Mild acute rejection episodes (within 6 months after LTx) · adult patients before and after liver transplantation.
Nutritional interventions for liver‐transplanted patients (2012) · Cochrane
OR 0.56 [0.19, 1.61]1 study · 71 participantsVery low
Nutritional supplement (500ml) and standard diet vs standard diet alone
Severe acute rejection episodes (within six months after LTx) · adult patients before and after liver transplantation.
Nutritional interventions for liver‐transplanted patients (2012) · Cochrane
OR 0.63 [0.22, 1.79]1 study · 71 participantsVery low
Enteral immunonutrion with Supportan vs enteral nutrition (EN) with Fresubin
Immunological rejection episodes · adult patients after liver transplantation.
Nutritional interventions for liver‐transplanted patients (2012) · Cochrane
no estimate extracted1 study · 84 participantsVery low
Hepatic product (HepaticAid) vs diet only (without supplement)
Infections [event per patient] · adult patients with malnutrition and encephalopathy before and after liver transplantation.
Nutritional interventions for liver‐transplanted patients (2012) · Cochrane
no estimate extracted1 study · 22 participantsVery low
Postoperative feeding via nasojejunal tube vs no postoperative parental nutrition (conventional intravenous electrolyte solution)
Days in hospital post liver transplantation · adult patients after liver transplantation.
Nutritional interventions for liver‐transplanted patients (2012) · Cochrane
no estimate extracted1 study · 31 participantsVery low
Postoperative feeding via nasojejunal tube vs no postoperative parental nutrition (conventional intravenous electrolyte solution)
Re‐hospitalisation [events per patient] · adult patients after liver transplantation.
Nutritional interventions for liver‐transplanted patients (2012) · Cochrane
no estimate extracted1 study · 31 participantsVery low
Postoperative feeding via nasojejunal tube vs no postoperative parental nutrition (conventional intravenous electrolyte solution)
Infections (overall) · adult patients after liver transplantation.
Nutritional interventions for liver‐transplanted patients (2012) · Cochrane
OR 0.32 [0.04, 1.86]1 study · 31 participantsVery low
Postoperative feeding via nasojejunal tube vs no postoperative parental nutrition (conventional intravenous electrolyte solution)
Infections (bacterial) · adult patients after liver transplantation.
Nutritional interventions for liver‐transplanted patients (2012) · Cochrane
OR 0.41 [0.03, 3.15]1 study · 31 participantsVery low
Postoperative feeding via nasojejunal tube vs no postoperative parental nutrition (conventional intravenous electrolyte solution)
Infections (viral) · adult patients after liver transplantation.
Nutritional interventions for liver‐transplanted patients (2012) · Cochrane
no estimate extracted1 study · 31 participantsVery low
Postoperative feeding via nasojejunal tube vs no postoperative parental nutrition (conventional intravenous electrolyte solution)
Intensive care unit length of stay after liver transplantation [hours] · adult patients after liver transplantation.
Nutritional interventions for liver‐transplanted patients (2012) · Cochrane
no estimate extracted1 study · 31 participantsVery low
Postoperative feeding via nasojejunal tube vs no postoperative parental nutrition (conventional intravenous electrolyte solution)
Time on ventilator [hours until initial extubation] · adult patients after liver transplantation.
Nutritional interventions for liver‐transplanted patients (2012) · Cochrane
no estimate extracted1 study · 31 participantsVery low
Postoperative enteral nutrition (Osmolite) via nasojejunal tube vs postoperative parenteral nutrition (PN)
Length of hospital stay after liver transplantation [days] · adult patients after liver transplantation.
Nutritional interventions for liver‐transplanted patients (2012) · Cochrane
no estimate extracted1 study · 24 participantsVery low
Postoperative enteral nutrition (Osmolite) via nasojejunal tube vs postoperative parenteral nutrition (PN)
Days on ventilator · adult patients after liver transplantation.
Nutritional interventions for liver‐transplanted patients (2012) · Cochrane
no estimate extracted1 study · 24 participantsVery low
Postoperative enteral nutrition (Osmolite) via nasojejunal tube vs postoperative parenteral nutrition (PN)
Mortality · adult patients after liver transplantation.
Nutritional interventions for liver‐transplanted patients (2012) · Cochrane
OR 0.7 [0.01, 60.29]1 study · 24 participantsVery low
Hepatic product (HepaticAid) vs diet only (without supplement)
Acute rejection [event per patient] · adult patients with malnutrition and encephalopathy before and after liver transplantation.
Nutritional interventions for liver‐transplanted patients (2012) · Cochrane
no estimate extracted1 study · 22 participantsVery low
Postoperative enteral nutrition (Osmolite) via nasojejunal tube vs postoperative parenteral nutrition (PN)
Side effects (vomiting, diarrhoea) · adult patients after liver transplantation.
Nutritional interventions for liver‐transplanted patients (2012) · Cochrane
OR 0.68 [0.04, 11.17]1 study · 24 participantsVery low